2012
DOI: 10.18632/aging.100505
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Abstract: Mitochondria are the dominant source of the cellular energy requirements through oxidative phosphorylation, but they are also central players in apoptosis. Nutrient availability may have been the main evolutionary driving force behind these opposite mitochondrial functions: production of energy to sustain life and release of apoptotic proteins to trigger cell death. Here, we explore the link between nutrients, mitochondria and apoptosis with known and potential implications for age-related decline and metaboli… Show more

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Cited by 32 publications
(19 citation statements)
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References 70 publications
(95 reference statements)
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“…Mitochondrial DNA encodes 37 genes that are all essential for oxidative phosphorylation to generate ATP. This study indicates that the incidence of mitochondrial dysfunction increases after TRI; however, the exact mechanisms that associate mitochondrial dysfunction, obesity, and aging with metabolic syndrome remain a topic of debate (Pintus et al 2012;Vernochet and Kahn 2012). The mechanism of TRI-induced weight gain is unclear and is likely due to multiple factors.…”
Section: Discussionmentioning
confidence: 82%
“…Mitochondrial DNA encodes 37 genes that are all essential for oxidative phosphorylation to generate ATP. This study indicates that the incidence of mitochondrial dysfunction increases after TRI; however, the exact mechanisms that associate mitochondrial dysfunction, obesity, and aging with metabolic syndrome remain a topic of debate (Pintus et al 2012;Vernochet and Kahn 2012). The mechanism of TRI-induced weight gain is unclear and is likely due to multiple factors.…”
Section: Discussionmentioning
confidence: 82%
“…We found that ASCs from formerly obese environments preserve a greater quantity of mitochondria such as oASCs (Figure A); however, ROS levels were significantly decreased compared with oASCs (Figure B), due perhaps to a stress‐reduced environment . These differences may be related to an increase in proliferation capacity and a proportionate reduction in apoptosis in dASCs . Because stem cell culturing leads to alterations in mitochondrial mass and changes in mitochondrial oxygen consumption, which is dependent on substrate availability , we have gauged their respiration capacity.…”
Section: Discussionmentioning
confidence: 99%
“…In their studies they demonstrated major mitochondrial metabolic differences between normal and obese subjects. Others have shown that nutritional imbalance leads to mitochondrial dysfunction and susceptibility to apoptosis with consequences such as insulin resistance 93 .…”
Section: Resultsmentioning
confidence: 99%