Nutraceutical Improves Glycemic Control, Insulin Sensitivity, and Oxidative Stress in Hyperglycemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Abstract

The aim of this research was to investigate the effects of nutraceuticals including bitter melon, fenugreek, cinnamon, alpha-lipoic acid, zinc, biotin, chromium, and cholecalciferol on glycemic control, insulin sensitivity, lipid profiles, oxidative stress, and inflammatory markers in hyperglycemia. The study design was a randomized, double-blind, placebo-controlled trial. Subjects with hyperglycemia were randomly divided into 2 groups. The treatment group ( n = 52) was given a nutraceutical and the control group ( n = 50) was provided with a placebo for 12 weeks. Fasting blood glucose (FBG), hemoglobin A1c (HbA1C), homeostatic model assessment of insulin resistance (HOMA-IR), lipid profiles, biomarkers of oxidative stress, and inflammation were assessed before and after the intervention at 6 weeks and 12 weeks. Nutraceutical supplementation demonstrated a statistically significant decrease in FBG (13.4% and 18.9%), HbA1C (6.5% and 11.3%), and HOMA-IR (28.9% and 35.2%) compared with the placebo. Moreover, low-density lipoprotein-cholesterol (LDL-C) level was significantly reduced in the nutraceutical group (7.1% and 9.3%). Furthermore, the nutraceutical significantly decreased oxidative stress markers, oxidized LDL-C (14.8% and 18.9%) and malondialdehyde (16.6% and 26.2%) compared with the placebo. In conclusion, this nutraceutical can improve glycemic control, insulin resistance, lipid profiles, and oxidative stress markers in hyperglycemic subjects. Therefore, it has the potential to decrease cardiovascular disease risk factors. Clinical trial registration: TCTR20180907001, www.clinicaltrials.in.th.

A systems biology-based mathematical model demonstrates the potential anti-stress effectiveness of a multi-nutrient botanical formulation

“…Acerola and Gotukola, integral to Nutrilite ® Daily Plus formulation, further contribute to this effect by influencing the AKT AMPK pathway, resulting in an increased antioxidant status. Moreover, Gotukola's enhancement of the NRF anti-inflammatory pathway leads to a substantial 79% reduction in inflammation, surpassing the 18% reduction reported in the study by Bumrungpert et al 56 .…”

Can probiotic, prebiotic, and synbiotic supplementation modulate the gut-liver axis in type 2 diabetes? A narrative and systematic review of clinical trials

“…A study by Shekarchizadeh-Esfahani et al concluded that administering cinnamon at daily dosages of <1,500 mg for at least 12 weeks significantly reduced ALT levels ( p = 0.002) ( 79 ). Although cinnamon’s effect on liver function remains unclear, several studies reported cinnamon’s interaction with peroxisome proliferator-activated receptor (PPAR) which ultimately improves insulin resistance, down-regulates pro-inflammatory cytokine levels, and decreases serum AST levels ( 79 , 80 ). Longe et al also looked at the hepatoprotective properties of cinnamon on alloxan induced diabetic rats ( 81 ).…”

A Citrus and Pomegranate Complex Reduces Methylglyoxal in Healthy Elderly Subjects: Secondary Analysis of a Double-Blind Randomized Cross-Over Clinical Trial

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