Nuphar lutea Extracts Exhibit Anti-Viral Activity against the Measles Virus

Winer, Hila; Ozer, Janet; Shemer, Yonat; Reichenstein, Irit; Eilam-Frenkel, Brit; Benharroch, Daniel; Golan‐Goldhirsh, Avi; Gopas, Jacob

doi:10.3390/molecules25071657

Cited by 11 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar investigations on the medicinal potentials of Nuphar extracts showed anti-bacterial activity [15]. Another study carried out on the extract of Nuphar lutea showed inhibitory effects on some bacteria [16,17] and against pathogenic fungi [18].…”

Section: Figure 4 Antioxidant Effects Of Crude Extracts Of Fungal End...mentioning

confidence: 59%

Antimicrobial and antioxidant potentials of crude extracts of culturally dissimilar endophytic fungi

Okezie¹,

Obi²,

Morikwe³

et al. 2023

GSC Biol. Pharm. Sci.

View full text Add to dashboard Cite

Endophytes from an unexplored plant such as Spatterdock (SD) Nuphar lutea variegata could be a dependable producer of novel secondary metabolites active against drug resistance organisms. This study explored the diversity of fungal endophytes from mid-rib (MR) and leaf blade (LB) of Nuphar lutea variegata as well as the antimicrobial and antioxidant potentials of their secondary metabolites. Morphological features observed showed four species were isolated. A broad-spectrum antimicrobial activity observed to be concentration-dependent was observed for all the fungal crude extracts 1 mg/mL. Crude extract of SD-LB3 showed the best antibacterial activities against S. aureus and P. aeruginosa with a minimum inhibitory concentration of 0.5 and 0.25 µg/mL respectively. The antioxidant capacities of the fungal crude extracts showed a better neutralizing effect of free radicals compared to the standard Quercitin. Effective inhibition of free radicals was observed for all the fungal extracts from 20 to 100 mg/mL (96.7 – 99.3 %). The highest antioxidant activity was shown by the extracts of fungi isolated from the leaf blade with an average of 98 to 99.2 % at the tested concentrations of 20 to 100 mg/mL. Our study provides evidence of diverse endophytic fungi associated with Nuphar lutea variegata, and the antibacterial and antioxidant activities observed confirm their capacities as producers of bioactive secondary metabolites. This study is the first to isolate endophytic fungi form Nuphar lutea variegata and screen the antimicrobial and antioxidant activities of their secondary metabolites.

show abstract

Section: Figure 4 Antioxidant Effects Of Crude Extracts Of Fungal End...mentioning

confidence: 59%

Antimicrobial and antioxidant potentials of crude extracts of culturally dissimilar endophytic fungi

Okezie¹,

Obi²,

Morikwe³

et al. 2023

GSC Biol. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…The antiviral property against MV was quantified by using qRT-PCR and the IC 50 value was determined (0.3 μg/mL). The authors also claim the inhibitory activity of the methanolic extract against Respiratory Syncytial Virus (RSV) [ 161 ].…”

Section: Antiviral Activity From Plant Extracts and Secondary Metabolitesmentioning

confidence: 99%

Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates

et al. 2021

View full text Add to dashboard Cite

Viral infections are among the most complex medical problems and have been a major threat to the economy and global health. Several epidemics and pandemics have occurred due to viruses, which has led to a significant increase in mortality and morbidity rates. Natural products have always been an inspiration and source for new drug development because of their various uses. Among all-natural sources, plant sources are the most dominant for the discovery of new therapeutic agents due to their chemical and structural diversity. Despite the traditional use and potential source for drug development, natural products have gained little attention from large pharmaceutical industries. Several plant extracts and isolated compounds have been extensively studied and explored for antiviral properties against different strains of viruses. In this review, we have compiled antiviral plant extracts and natural products isolated from plants reported since 2015.

show abstract

“…Natural products of Nuphar lutea (L.) Sm. (Nymphaeaceae) have been widely used for treating inflammatory conditions in ethnic medicine [ 1 , 2 ]. A systematic review of early studies revealed that the full therapeutic potential of Nuphar products is still largely unexplored by modern research [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…(NUP), is enriched in sesquiterpene thioalkaloids, such as nupharidine and bi-nupharidine isomers [ 4 ]. A variety of therapeutic applications have been described: anti-inflammatory [ 2 ], antibacterial [ 5 , 6 ], antiviral [ 1 ], against pathogenic fungi [ 7 ], against leishmania, and trypanosome parasites, [ 8 , 9 , 10 ], and against cancer. We previously examined the effect of NUP extracts in B16 melanoma, experimental murine lung metastasis model, and in a variety of cell lines, demonstrating its ability to affect ERK and NF-κB pathways.…”

Section: Introductionmentioning

confidence: 99%

6,6′-Dihydroxythiobinupharidine (DTBN) Purified from Nuphar lutea Leaves Is an Inhibitor of Protein Kinase C Catalytic Activity

et al. 2021

Self Cite

View full text Add to dashboard Cite

Water lily (Nuphar) bioactive extracts have been widely used in traditional medicine owing to their multiple applications against human ailments. Phyto-active Nuphar extracts and their purified and synthetic derivatives have attracted the attention of ethnobotanists and biochemists. Here, we report that 6,6′-dihydroxythiobinupharidine (DTBN), purified from extracts of Nuphar lutea (L.) Sm. leaves, is an effective inhibitor of the kinase activity of members of the protein kinase C (PKC) family using in vitro and in silico approaches. We demonstrate that members of the conventional subfamily of PKCs, PKCα and PKCγ, were more sensitive to DTBN inhibition as compared to novel or atypical PKCs. Molecular docking analysis demonstrated the interaction of DTBN, with the kinase domain of PKCs depicting the best affinity towards conventional PKCs, in accordance with our in vitro kinase activity data. The current study reveals novel targets for DTBN activity, functioning as an inhibitor for PKCs kinase activity. Thus, this and other data indicate that DTBN modulates key cellular signal transduction pathways relevant to disease biology, including cancer.

show abstract

Nuphar lutea Extracts Exhibit Anti-Viral Activity against the Measles Virus

Cited by 11 publications

References 38 publications

Antimicrobial and antioxidant potentials of crude extracts of culturally dissimilar endophytic fungi

Antimicrobial and antioxidant potentials of crude extracts of culturally dissimilar endophytic fungi

Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates

6,6′-Dihydroxythiobinupharidine (DTBN) Purified from Nuphar lutea Leaves Is an Inhibitor of Protein Kinase C Catalytic Activity

Contact Info

Product

Resources

About