Numerical evaluation of the capping tendency of microcrystalline cellulose tablets during a diametrical compression test

Furukawa, Ryoichi; Chen, Yuan; Horiguchi, Akio; Takagaki, Keisuke; Nishi, Junichi; Konishi, Akira; Shirakawa, Yoshiyuki; Sugimoto, Masaaki; Narisawa, Shinji

doi:10.1016/j.ijpharm.2015.07.029

Cited by 29 publications

(10 citation statements)

References 40 publications

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“…To validate the FE model in this study, axial pressure as a function of axial displacement; and thickness of tablet as a function of compaction pressure were considered. These parameters were used for validating the FE model of a tableting process in previous studies [10], [12], [13], [19]. The accurate prediction of the tablet thickness not only ensures that the simulated tablet has an identical shape to the actual tablet one but also indicates that both tablets have the same average density and thus have comparable density variation within the tablet.…”

Section: Validation Of Fe Modelmentioning

confidence: 99%

“…However, numerical computational modelling tools, such as Finite Element Method (FEM), are very useful techniques providing access to unique results that cannot readily be attained from experimental tests. Recently, modelling techniques were successfully implemented to attain a better insight on the various aspects of the tabletting process such as tablet failure mechanism [6], [7], [8], [9], [10], temperature evolution during the process [8], [11], stress and density distributions within the tablet [12], effect of punch shape [6], [13], and effect of friction [14].…”

Section: Introductionmentioning

confidence: 99%

“…Furukawa et al [10] estimated capping tendency in single-radius and double-radius tablets using a simple method that is based on the variation in plastic strain during a diametrical compression test. Authors used numerical simulations to calculate plastic strains.…”

Section: Introductionmentioning

confidence: 99%

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Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

2019

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Capping failure, edge chipping, and non-uniform mechanical properties of convexfaced pharmaceutical tablets are common problems in pharma industry. In this paper, Finite Element Modelling (FEM) and Design of Experiment (DoE) techniques are adopted to find the optimal shape of convex-faced (CF) pharmaceutical tablet which has more uniform mechanical properties and less capping and chipping tendency. The effects of the geometrical parameters and friction on the compaction responses of convex-faced pharmaceutical tablets were first identified and analysed. The finite element model of the tabletting process was generated using the implicit code (ABAQUS) and validated against experimental measurements. Response Surface Methodology (RSM) was employed to establish the relationship between the design variables, represented by the geometrical parameters and the friction coefficient, and compaction responses of interest including residual die pressure, the variation of relative density within the tablet, and the relative shear stress of the edge of the tablet. A statistical-based optimisation approach is then employed to undertake shape optimisation of CF tablets. The obtained results demonstrated how the geometrical parameters of CF tablet and the friction coefficient have significant effects on the compaction behaviour and quality of the pharmaceutical tablet.

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Section: Validation Of Fe Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

2019

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“…(2015) [8] who sought out to determine an effective method for evaluating the capping tendency during a diametral compression test of pharmaceutical tablets (microcrystalline cellulose) using FE. Experimental work by Procopio et al (2003) [9] found that this relationship is accurate for linear elastic materials of which are brittle and will fracture.…”

Section: Introductionmentioning

confidence: 99%

Diametral compression test method to analyse relative surface stresses in thermally sprayed coated and uncoated circular disc specimens

Faisal

Mann

Duncan

et al. 2019

Surface and Coatings Technology

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“…They demonstrated that the position of the breaking line significantly affected the breaking strength of scored tablets. Although numerous FEM simulation studies evaluating the powder compaction and mechanical strength of tablets have been reported, [5][6][7][8][9][10][11][12][13][14][15][16][17] very little is known regarding the mechanical adequacy of score shapes involving dividing strength, halving equality, and breaking strength. The aim of this study was to clarify the effect of score shapes on the essential characteristics of tablets by using FEM simulation.…”

mentioning

confidence: 99%

Mechanical Stress Simulation of Scored Tablets Based on the Finite Element Method and Experimental Verification

Okada

Hayashi

Onuki

et al. 2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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Scored tablets can be divided into equal halves for individual treatment of patients. However, the relationships between scored shapes and tablet characteristics such as the dividing strength, halving equality, and breaking strength are poorly understood. The purpose of this study was to simulate the mechanical stress distribution of scored tablets by using the finite element method (FEM). A runnel of triangle pole on the top surface of flat tablets was fabricated as the score shape. The depth and angle of the scores were selected as design variables. Elastic parameters such as a Young's modulus and a Poisson ratio for the model powder bed were measured. FEM simulation was then applied to the scored tablets, represented as a continuum elastic model. Stress distributions in the inner structure of the tablets were simulated after applying external force. The adequacy of the simulation was evaluated in experiments using scored tablets. As a result, we observed a relatively good agreement between the FEM simulation and the experiments, suggesting that FEM simulation is advantageous for designing scored tablets.

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Numerical evaluation of the capping tendency of microcrystalline cellulose tablets during a diametrical compression test

Cited by 29 publications

References 40 publications

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

Diametral compression test method to analyse relative surface stresses in thermally sprayed coated and uncoated circular disc specimens

Mechanical Stress Simulation of Scored Tablets Based on the Finite Element Method and Experimental Verification

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