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Cited by 22 publications
(16 citation statements)
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“…DCI itself is known as an effective activator even though it has a relatively high pK a , presumably because it is a better nucleophile [ 32 ]. In order to determine if alternative activators could be used to shorten the coupling time, we tested and compared five activators which have been suggested in the literature as effective activators: DCI, 5-ethylthio-1 H -tetrazole (ETT) [ 34 ], 5-benzylthio-1 H -tetrazole (BTT) [ 35 ], 5-[3,5-Bis(trifluoro-methyl)—phenyl]-1 H -tetrazole (Activator 42) [ 36 ], and pyridinium chloride [ 37 ].…”
Section: Resultsmentioning
confidence: 99%
“…DCI itself is known as an effective activator even though it has a relatively high pK a , presumably because it is a better nucleophile [ 32 ]. In order to determine if alternative activators could be used to shorten the coupling time, we tested and compared five activators which have been suggested in the literature as effective activators: DCI, 5-ethylthio-1 H -tetrazole (ETT) [ 34 ], 5-benzylthio-1 H -tetrazole (BTT) [ 35 ], 5-[3,5-Bis(trifluoro-methyl)—phenyl]-1 H -tetrazole (Activator 42) [ 36 ], and pyridinium chloride [ 37 ].…”
Section: Resultsmentioning
confidence: 99%
“…Coupling was done twice for 120 s with 50 mm phosphoramidite soln. in MeCN and 0.5m pyridine hydrochloride as the activator of choice [17]. The temporary 3'-nppoc groups were removed by light exposure (100-W Hg lamp; 5 min at 365 nm) in presence of 50 mm i Pr 2 NEt.…”
Section: '-O-{[2-(2-nitrophenyl)propoxy]carbonyl}thymidine 5'-(2-cyamentioning
confidence: 99%
“…The cytidine derivative 12 was conveniently isolated by precipitation. The final phosphitylation of the 5'-hydroxy group was accomplished in the usual manner by reaction with cyanoethyl tetraisopropylphosphorodiamidite in the presence of pyridine hydrochloride [17] as a mild acidic catalyst instead of the commonly used 1H-tetrazole. By this procedure, all four monomeric building blocks 15 ± 18 were obtained in high yield.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, an improved coupling step, brought about by the use of pyridinium chloride [14] instead of the commonly applied 1H-tetrazole, is recommended.…”
mentioning
confidence: 99%