Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia

Abstract

Background: Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expression detected by immunohistochemical staining in the normal oral epithelium and in the oral leukoplakia with or without dysplasia.

Association of differential β‐catenin expression with Oct‐4 and Nanog in oral squamous cell carcinoma and their correlation with clinicopathological factors and prognosis

“…The absence of membranous and subsequent intracellular expression of β-catenin was 16 found to be a key event in oral cancer [9]. In the present study, absence of membranous and intense intracellular expression of β-catenin was mainly observed in oral carcinoma and CAL27 cells which were concurrent with earlier reports by Ishida et al [9] and Kobayashi et al [33].…”

“…In the present study, absence of membranous and intense intracellular expression of β-catenin was mainly observed in oral carcinoma and CAL27 cells which were concurrent with earlier reports by Ishida et al [9] and Kobayashi et al [33]. This suggests that the β-catenin pathway might be re-activated and involved in oral carcinogenesis.…”

“…In addition to its role in maintaining stemness of embryonic stem cells, β-catenin was found to have a significant role in several tumors including oral squamous cell carcinoma, particularly the malignant transformation of oral dysplasia is associated with the intracellular expression of β-catenin. [5,9]. The expression of β-catenin was associated with invasion and metastasis of oral carcinoma cells thereby leading to poor prognosis [5].…”

Epithelial-Mesenchymal Interactions in Oral Cancer Metastasis

“…Loss of membranous ß-catenin and E-cadherin associated with EMT have been shown to correlate with metastatic formation and poor prognosis in multiple solid tumors and is a common feature of OSCC (Kudo et al, 2004;Odajima et al, 2005;Tanaka et al, 2003;Wang and Ma, 2007;Williams et al, 1998). Several studies have demonstrated that cytoplasmic and nuclear localization of -catenin is correlated with tumor progression, invasion and metastatic potential of OSCC (Ishida et al, 2007;Lo Muzio et al, 1999;Odajima et al, 2005;Yu et al, 2005). Cytoplasmic/nuclear -catenin expression has also been found to significantly correlate with EGFR expression in OSCC (Odajima et al, 2005).…”

Avaliação da expressão de β-catenina e ciclina D1 como biomarcadores preditivos para o câncer de lábio

“…Quando presente no citoplasma, na ausência da ativação da via de sinalização de Wnt, a β-catenina é degradada por um complexo multiprotéico formado por APC, Axin e GSK3β. Porém, quando ocorre alguma mutação genética que ativa a via de sinalização de Wnt, a β-catenina deixa de ser degradada e acumula-se no citoplasma (MACDONALD; TAMAI; HE, 2009; SCHUSSEL; PINTO JÚNIOR; MARTINS, 2011;TIAN et al, 2011).Dessa forma a β-catenina pode translocar-se ao núcleo e atuar na transcrição de oncogenes envolvidos no aumento da proliferação celular, como a ciclina D1 (IWAI et al, 2005;ODAJIMA et al, 2005;ISHIDA et al, 2007;GONZALEZ-MOLES et al, 2014b).…”