Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer

Merikallio, Heta; Pääkkö, Paavo; Kinnula, Vuokko L.; Harju, Terttu; Soini, Ylermi

doi:10.1016/j.humpath.2011.05.024

Cited by 53 publications

(49 citation statements)

References 34 publications

(62 reference statements)

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“…Glioma patients with high Nrf2 expression had significantly shorter OS and DFS than glioma patients with low Nrf2 expression. Our results are consistent with the results reported in previous studies, in which high Nrf2 expression indicated the poor outcomes in malignant tumors [8][9][10]. In addition, high Nrf2 expression correlates with high tumor grade and indicates high degree of malignancy in gliomas.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, some in vitro and in vivo studies reported that overexpression of Nrf2 was associated with cancer chemoresistance/ radioresistance [23,25]. Nrf2 can protect cancer cells from the oxidative damage induced by radiation and chemotherapeutic agents [8]. Berberat et al [26] reported that suppression of the Nrf2 target HO-1 using siRNA caused a decrease in proliferation and the increased sensitivity to gemcitabine in pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

“…However, the protective effects of Nrf2 cannot discriminate the normal cells from cancer cells [7]. It has been demonstrated that high levels of Nrf2 promote cancer cell survival; contribute to chemoresistance; and associate with poor prognosis in a variety of malignant tumors, such as lung cancer, pancreatic cancer, and breast cancer [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of nuclear factor erythroid-derived 2–like 2 and p62/sequestosome expression on prognosis of patients with gliomas

Zhao

Zhang

et al. 2015

Human Pathology

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of nuclear factor erythroid-derived 2–like 2 and p62/sequestosome expression on prognosis of patients with gliomas

Zhao

Zhang

et al. 2015

Human Pathology

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“…Xiu-Feng Hu, Jun Yao, She-Gan Gao, Xin-Shuai Wang, Xiu-Qing Peng, YanTong Yang, Xiao-Shan Feng* (Merikallio et al, 2012). High Nrf2 expression predicts chemoresistance and tumor progression in patients with advanced-stage non-small-cell lung cancer (Yang et al, 2011).…”

Section: Nrf2 Overexpression Predicts Prognosis and 5-fu Resistance Imentioning

confidence: 99%

Nrf2 Overexpression Predicts Prognosis and 5-FU Resistance in Gastric Cancer

Yao²,

Gao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Lung cancer patients with upregulation of Nrf2 have lower survival rates (Merikallio et al 2012). Inhibition of Nrf2 in cervical carcinoma cells reduced tumor growth and elevated sensitivity to chemotherapy (Ma et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Sodium Selenite Inhibits Proliferation of Gastric Cancer Cells by Inducing SBP1 Expression

Gong

2016

Tohoku J. Exp. Med.

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Selenium is an essential trace element with an inhibitory effect on many types of human cancers, including gastric cancer. Selenium-binding protein 1 (SBP1) has been shown as a possible mediator of selenium's anti-cancer functions. Indeed, SBP1 was downregulated in gastric cancer, which is related with poor prognosis. However, the molecular mechanisms underlying the anti-tumor effects of SBP1 remain poorly understood. In this study, we aimed to assess the effects of selenium and/or SBP1 on the proliferation of gastric cancer cells. We used SGC7901 and N87 human gastric cancer cell lines and nude mice carrying subcutaneously implanted SGC7901 cells. Treatment with sodium selenite for 48 h caused the inhibition of cell proliferation and the increase in apoptosis of SGC7901 and N87 cells. Furthermore, sodium selenite increased the expression level of SBP1 and decreased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and the Wnt pathway components and its downstream targets, including β-catenin, GSK-3β, c-myc and cyclinD1 in these cell lines. However, these effects of sodium selenite were attenuated in SGC7901 and N87 cells by knockdown of SBP1 expression. Thus, the sodium selenite-induced SBP1 expression is associated with the inhibition of cell proliferation and with the induced apoptosis. Importantly, sodium selenite treatment retarded the growth of the transplanted SGC7901 cells in nude mice, with the induction of SBP1 expression, which was associated with the decrease of Nrf2 expression and the inactivation of the Wnt/β-catenin signaling pathway. We suggest that sodium selenite may have a potential application in gastric cancer treatment.

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Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer

Cited by 53 publications

References 34 publications

Impact of nuclear factor erythroid-derived 2–like 2 and p62/sequestosome expression on prognosis of patients with gliomas

Impact of nuclear factor erythroid-derived 2–like 2 and p62/sequestosome expression on prognosis of patients with gliomas

Nrf2 Overexpression Predicts Prognosis and 5-FU Resistance in Gastric Cancer

Sodium Selenite Inhibits Proliferation of Gastric Cancer Cells by Inducing SBP1 Expression

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