Nrf2 regulates the activation-driven expansion of CD4+T-cells by differentially modulating glucose and glutamine metabolism
Aprajita Tripathi,
Debolina Dasgupta,
Anil Pant
et al.
Abstract:Upon antigenic stimulation, CD4+T-cells undergo clonal expansion, elevating their bioenergetic demands and utilization of nutrients like glucose and glutamine. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a well-known regulator of oxidative stress, but its involvement in modulating the metabolism of CD4+T-cells remains unexplored. Here, we elucidate the role of Nrf2 beyond the traditional antioxidation, in modulating activation-driven expansion of CD4+Tcells by influencing their nutrient metabolis… Show more
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