Nrf2 protects against diverse PM2.5 components-induced mitochondrial oxidative damage in lung cells

Pardo, Michal; Fang, Xu; Shemesh, Mordechai; Qiu, Xinghua; Barak, Yoav; Zhu, Tong; Rudich, Yinon

doi:10.1016/j.scitotenv.2019.01.436

Cited by 67 publications

(57 citation statements)

References 63 publications

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“…MtDNAcn can be used as another indicator of mitochondrial damage because it correlates with the size and number of mitochondria in a cell and may change under different cellular energy demands or different physiological or environmental conditions [33,54]. Recent studies have correlated ambient PM exposure with mitochondrial DNA damage [26,33,54]. Similar to our study, a previous study found that personal exposure to fine PM and benzo [a] pyrene from indoor air pollution reduced MtDNAcns in leukocytes of women from China [55].…”

Section: Early Apoptotic Cells Can Become Late Apoptotic Cells If Thesupporting

confidence: 86%

“…The watersoluble wood tar extracts used in this study had low PAH contents. However, they were more toxic with respect to cellular bioenergetics than the organic extracts from samples from Beijing used in our previous study, which were collected in winter and dominated by PAHs from coal combustion [33].…”

Section: Early Apoptotic Cells Can Become Late Apoptotic Cells If Thementioning

confidence: 61%

“…This finding may imply that increased ROS levels, alterations in oxidative stress status, and cell death via apoptosis are consecutive events following mitochondrial damage. We have previously shown that exposure of cells to organic extracts containing high PAH levels reduces the rates of cellular bioenergetic processes (both the OCR and the ECAR) [33]. The watersoluble wood tar extracts used in this study had low PAH contents.…”

Section: Early Apoptotic Cells Can Become Late Apoptotic Cells If Thementioning

confidence: 72%

Section: Early Apoptotic Cells Can Become Late Apoptotic Cells If Thementioning

confidence: 99%

“…In the last few years, a major effort has been focused on finding associations between specific components in air pollution and human health effects [25,27,[30][31][32][33]. It was previously suggested that the toxicity of WSPs is strongly dependent on the organic fraction and is associated with organic components other than PAHs [25].…”

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confidence: 99%

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Mechanisms of lung toxicity induced by biomass burning aerosols

Pardo

et al. 2020

Part Fibre Toxicol

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Background: Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related impacts and toxicity are still not well known. This study investigated the toxicity of the water-soluble fraction of pyrolyzed wood tar aerosols in exposed mice and lung epithelial cells.Results: Mice exposed to water-soluble wood tar aerosols showed increased inflammatory and oxidative stress responses. Bronchial epithelial cells exposed to the same water-soluble wood tar aerosols showed increased cell death with apoptotic characteristics. Alterations in oxidative status, including changes in reactive oxygen species (ROS) levels and reductions in the expression of antioxidant genes related to the transcription factor Nrf2, were observed and were confirmed by increased levels of MDA, a lipid peroxidation adduct. Damage to mitochondria was observed as an early event responsible for the aforementioned changes. Conclusions:The toxicity and health effect-related mechanisms of water-soluble wood tar were investigated for the first time in the context of biomass burning. Wood tar particles may account for major responses such as cell death, oxidative stress, supression of protection mechnaisms and mitochondrial damaged cause by expsoure to biomass burning aerosols.

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