Novel Use of a Volumizing Hyaluronic Acid Filler for Treatment of Infraorbital Hollows

Abstract

IMPORTANCE Hyaluronic acid filler can be safely used as a soft-tissue filler for correction of infraorbital hollowing. It has a high overall patient satisfaction profile among patients. OBJECTIVE To report safety and patient satisfaction outcomes of Juvéderm Voluma XC for correction of infraorbital hollows. DESIGN, SETTING, AND PATIENTSThis was a retrospective observational study performed at a private ambulatory facial plastic and reconstructive surgery practice. Participants were all patients 21 to 85 years old who presented to our practice and underwent Juvéderm Voluma XC treatment for correction of infraorbital hollows as a singular intervention from February 2016 to March 2017. INTERVENTIONS Injection of JuvédermVoluma XC to the tear trough, nasojugal fold, and/or palpebromalar groove. MAIN OUTCOMES AND MEASURESPrimary outcome measures include the number of recorded short-and long-term adverse events, need for additional treatment, and patient questionnaire FACE-Q scores.RESULTS A total of 202 eyes were treated in 101 patients with a mean follow-up of 12 months. Patients were principally female (90 [89%]) with an average age of 54 years (range, 21-85 years). Most patients (99) had Fitzpatrick grade 1 to 4 skin type (98%) and had an infraorbital hollows score of 2 to 4 (89 [88%]). The average initial treatment volume was 1 mL with 18 patients (18%) requiring additional treatment within 3 months. The average time until additional treatment was 35.7 days. Adverse effects include bruising (in 10 [10%], contour irregularities (2 [2%]), swelling (3 [3%]), and Tyndall effect (1 [1%]). Hyaluronidase was required in 3 patients (3%). Forty-one patients completed the FACE-Q Satisfaction With Eyes survey, and 42 patients completed the FACE-Q Satisfaction With Decision survey (41% and 42%). Overall mean (SD) patient satisfaction (based on FACE-Q scores) was 71.1% (27.3) and 65.6% (31.3), respectively.CONCLUSIONS AND RELEVANCE Juvéderm Voluma XC has a high patient satisfaction profile and an acceptable safety profile for the correction of infraorbital hollowing.LEVEL OF EVIDENCE 4.

Improvements in satisfaction with skin after treatment of facial fine lines with VYC‐12 injectable gel: Patient‐reported outcomes from a prospective study

“…This is the first analysis using a validated PRO instrument, the FACE‐Q, in a clinical study of the safety and effectiveness of an injectable HA filler for the treatment of fine lines and improvements in attributes of skin quality. FACE‐Q improvements in studies of injectable HA fillers have been shown previously; however, these studies either included a combination of treatments or involved injections in limited regions of the face . This prospective study in 131 subjects demonstrated that injections of VYC‐12 in the full face, with optional treatment in the neck, yielded significant improvements in PRO measures.…”

Hyaluronic acid for lower eyelid and tear trough rejuvenation: review of the literature

“…The reported follow-up duration, when mentioned, ranged from 12 months [29] to 5 years [39,69] , with prolonged edema, the Tyndall effect and contour irregularities as the most commonly reported complications, along with diplopia [25] , and xanthelasma-like reactions [53] as a rare occurrence. Complications were also reported in several articles, even if not the focus of the study [13,17,22,28,32,[71][72][73][74][75] , and included two cases of cellulitis and one of migraine [13] .…”

“…Research focused on personal techniques purposed by the authors have been published since 2005. Airan and Born [11] and Kane [12] wrote the first articles ever about this topic, both in 2005; technique refinement and new trends have been published in 2006 [22,23] , 2007 [24,33] , 2011 [16,32,76] , 2012 [26,41,42,66] , 2013 [73] , 2014 [43] , 2015 [48][49][50] , 2016 [27,28] , 2017 [17,52] , 2018 [19,71,74] and 2019 [21] .…”

Chitosan biopolymer‐derived self‐powered triboelectric sensor with optimized performance through molecular surface engineering and data‐driven learning

“…Figure B shows that a typical Tyndall effect can be seen for the samples with chitosan/citric acid mass ratios from 1:2 to 1:6, where a laser beam passes through the colloidal chitosan solution leaving a clear track due to light scattering. However, the sample with a 1:1 mass ratio has no significant Tyndall effect, which can be attributed to the large size fragments, due to the insufficient degree of hydrolysis when the acid concentration was too low . The large chitosan fragmentation hinders the further formation of an integral 3D chitosan network .…”

“…However, the sample with a 1:1 mass ratio has no significant Tyndall effect, which can be attributed to the large size fragments, due to the insufficient degree of hydrolysis when the acid concentration was too low. 69 The large chitosan fragmentation hinders the further formation of an integral 3D chitosan network. 70 Consequently, the mass ratios between chitosan and citric acid from 1:2 to 1:6 (marked as CC-1, CC-2, CC-3, CC-4, and CC-5, respectively) are selected for the formation of chitosan film in the following device fabrication.…”