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“…Reagents R16 was synthesized as previous reported (16), and its purity was more than 99%. Amonafide was obtained from the Drug Synthesis and Chemistry Branch, Division of Cancer Treatment, National Cancer Institute (Berthda, MA).…”
Section: Methodsmentioning
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“…Reagents R16 was synthesized as previous reported (16), and its purity was more than 99%. Amonafide was obtained from the Drug Synthesis and Chemistry Branch, Division of Cancer Treatment, National Cancer Institute (Berthda, MA).…”
Section: Methodsmentioning
“…1; ref. 16). One of the major strategies in this regard has been to improve the intercalation and photocleavage to DNA by chemical modification.…”
Section: Introductionmentioning
“…The antitumor activity of any compound can be determined by many factors, including cell membrane crossing ability, protein transport, DNA binding ability and drug metabolism [20]. Previous studies have demonstrated that compounds with strong DNAbinding affinity are highly cytotoxic [37].…”
Section: Dna Binding Studymentioning
“…The role of the sulfur atom in improving antitumor activities has been reported. Previous studies showed that especially sulfur-containing derivatives exhibited promising antiproliferative efficiency towards several tumor cell lines [19,20]. Dithiocarbamates have been attracting considerable interest because of their diverse activities [21][22][23][24] and in the treatment of cancer [25,26].…”
Section: Introductionmentioning
“…For example, the thiazolium ring is present in vitamin B [11,12]. Also, large number of thiazole derivatives has emerged as active pharmaceutical ingredients in several drugs for their potential anti-inflammatory [13] and antitumor activities [14]. A part of our studies is directed toward exploring the synthetic potential of nitriles as precursors of biologically active heterocyclic nitrogenous compounds, such as pyrazoles, thiazoles, pyridines, quinazolines, chromenes and their condensed systems [15][16][17][18][19][20][21][22][23].…”
Section: Introductionmentioning