Novel “soft” biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system

Jäger, Alessandro; Gromadzki, Daniel; Jäger, Eliézer; Giacomelli, Fernando C.; Kozłowska, A.; Kobera, Libor; Brus, Jiřı́; Řı́hová, Blanka; Fray, Mirosława El; Ulbrich, Karel; Štěpánek, Petr

doi:10.1039/c2sm07247e

Cited by 58 publications

(65 citation statements)

References 58 publications

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“…The refractive index increment (dn/dc) of the PBS/PBDL NPs in pure water (0.153 mL·g −1 ) and PHPMA-chol (0.167 mL·g −1 ) was taken from our previous literature data [20,25]. The concentrations and refractive index increments of the core-shell NPs as a function of the molar mixing ratio were estimated on the basis of the complex formation model [26].…”

Section: Static Light Scattering (Sls)mentioning

confidence: 99%

“…The number average molecular weight (M n ) and molecular weight distribution (polydispersity, M w /M n ) of the synthesized copolymer were determined using SEC [20]. Tetrahydrofuran (THF) was used as the mobile phase at a flow rate of 0.5 mL·min −1 .…”

Section: Synthesis and Characterization Of The Copolyestermentioning

confidence: 99%

“…The synthesis of the aliphatic copolyester was performed following a previously described two-step melt polycondensation (esterification and polycondensation) protocol [19,20]. SA, DLA and BD were loaded into a glass reactor in a 1/2.2 molar ratio with the catalyst TBT (4× 10 −4 mol/mol diacids).…”

Section: Synthesis and Characterization Of The Copolyestermentioning

confidence: 99%

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Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester

Jäger

Chytil

et al. 2013

Journal of Controlled Release

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Section: Static Light Scattering (Sls)mentioning

confidence: 99%

Section: Synthesis and Characterization Of The Copolyestermentioning

confidence: 99%

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Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester

Jäger

Chytil

et al. 2013

Journal of Controlled Release

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“…It can be synthesized through condensation polymerization of 1,4-butanediol and succinic acid [13]. In light of its biodegradability and harmless degradation products, PBS has been used as a novel biomaterial for tissue engineering [14][15][16][17] and drug delivery [18][19][20]. However, there are few reports focusing on the preparation of PBS foams.…”

Section: Introductionmentioning

confidence: 99%

Preparation of biodegradable poly(butylene succinate)/halloysite nanotube nanocomposite foams using supercritical CO2 as blowing agent

Cao

Lin

et al. 2015

J Polym Res

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Biodegradable poly(butylene succinate) (PBS) was melt compounded with halloysite nanotube (HNT) to prepare PBS/HNT nanocomposites, and both pure PBS and PBS/ HNT nanocomposites were foamed successfully using supercritical carbon dioxide as a physical blowing agent. The cell morphologiesshowed that the cell size decreased, and both cell density and volume expansion ratio increased with the addition of HNT. Within the HNT content used in this work (1, 3, 5, and 7 wt.%), the content of 5 wt.% was found to be the one that lead to the smallest cell size and highest cell density and volume expansion ratio. In addition to the HNT content, both saturation temperature and saturation pressure were found to significantly influence the cell morphology. Higher saturation pressure led to smaller cell size and higher volume expansion ratio. Interestingly, a close-celled to interconnect open-celled morphology transition occurred for PBS/HNT nanocomposites at a saturation temperature of 120°C. The formation of interconnect open-celled morphology was mainly attributed to the stress induced by the HNT in the cell solidification process. With the increase of HNT content, saturation temperature and saturation pressure, the enthalpy of fusion of the foamed samples increased.

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“…13 Furthermore, nanoprecipitation studies usually deal with low-molar-mass polymers which behave as liquids and coalesce into compact particles, 14 the size of which scales with the aggregation number as R ~ N agg 1/3 . In this paper, we present a study of nanoparticles prepared by nanoprecipitation of cellulose-graft-polystyrene (Cel-g-PS) copolymers with the molar mass of the order of 10 6 g mol -1 and high grafting densities.…”

Section: Introductionmentioning

confidence: 99%

Structure of polymeric nanoparticles in surfactant-stabilized aqueous dispersions of high-molar-mass hydrophobic graft copolymers

Hajduová

Procházka

Raus

et al. 2014

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Aqueous dispersions of hydrophobic high-molar-mass cellulose-graft-polystyrene (Cel-g-PS) copolymers were prepared by nanoprecipitation from dioxane solutions using sodium dodecyl sulfate as a stabilizer. The size and structure of formed Cel-g-PS nanoparticles were studied by scattering techniques (static and dynamic light scattering, SAXS) and transmission electron microscopy. The scattering and microscopy data show that nanoprecipitation of Cel-g-PS leads to the formation of polydisperse aggregates of collapsed Cel-g-PS macromolecules containing entrapped SDS micelles in the kinetically frozen state.The final size of the aggregates can be tuned by changing the copolymer concentration, c P , in the dioxane solution. The average hydrodynamic radius of the aggregates, R H , scales as-1] ~ c P , where R H,0 is the R H value extrapolated to the zero copolymer concentration.

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Novel “soft” biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system

Cited by 58 publications

References 58 publications

Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester

Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester

Preparation of biodegradable poly(butylene succinate)/halloysite nanotube nanocomposite foams using supercritical CO2 as blowing agent

Structure of polymeric nanoparticles in surfactant-stabilized aqueous dispersions of high-molar-mass hydrophobic graft copolymers

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