2014
DOI: 10.2174/1573406410666140327122009
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Abstract: The synthesis and chemical characterization of the novel 2,6-diacetylpyridine-bis(selenosemicarbazone) metal complexes of Zn(II), Cd(II) and Ni(II) were published previously. Here we report first evidence on anti-proliferative activity of the complexes and molecular patterns that underlie it. The complexes and the corresponding ligand are shown to be cytotoxic on the panel of nine, malignant and non-malignant cell lines, with the exception of Ni(II) complex that did not achieve IC50 value on any of the cell li… Show more

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Cited by 24 publications
(15 citation statements)
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“…In some cases, such as I-CRP, there is an activity of caspases but this activity is not necessary to carry out the cell death, this is because the caspases can be involved in non-lethal cell processes such as differentiation, normal cell signalling and maturation [ 46 ], in addition to their immune functions [ 47 ]. Like I-CRP other agents also induce activation of caspases but kill cancer cells through a caspase-independent mechanism, such it is the case of bisanthracycline WP 631 [ 48 ], selenosemicarbazone metal complexes [ 49 ], phenoxazine derivatives [ 50 ], among others. Many of these agents induce caspase-independent cell death mechanisms that have been well documented and whose characterization has helped to determine shared features of these types of cell death modalities, such is the case of matrine [ 51 ] and methylnitronitrosoguanidine (MNNG) [ 52 , 53 ], that induce mitochondrial damage, and subsequently AIF-dependent cell death.…”
Section: Discussionmentioning
confidence: 99%
“…In some cases, such as I-CRP, there is an activity of caspases but this activity is not necessary to carry out the cell death, this is because the caspases can be involved in non-lethal cell processes such as differentiation, normal cell signalling and maturation [ 46 ], in addition to their immune functions [ 47 ]. Like I-CRP other agents also induce activation of caspases but kill cancer cells through a caspase-independent mechanism, such it is the case of bisanthracycline WP 631 [ 48 ], selenosemicarbazone metal complexes [ 49 ], phenoxazine derivatives [ 50 ], among others. Many of these agents induce caspase-independent cell death mechanisms that have been well documented and whose characterization has helped to determine shared features of these types of cell death modalities, such is the case of matrine [ 51 ] and methylnitronitrosoguanidine (MNNG) [ 52 , 53 ], that induce mitochondrial damage, and subsequently AIF-dependent cell death.…”
Section: Discussionmentioning
confidence: 99%
“…Duprez also revealed that the inhibitor of RIPK1 (Nec-1) or deletion of RIPK3 (RIPK3 deficiency) could protect against systemic inflammatory response syndrome (SIRS) and sepsis [19]. Moreover, in lung cancer treatment, necroptosis exerted important roles in anti-tumor effect [20]. However, the functions and detailed mechanisms of necroptosis in PM–related pulmonary disorders still remain largely unknown.…”
Section: Introductionmentioning
confidence: 99%
“…This general class of compounds has been shown to possess a wide range of bioactive properties, including antitumor activity. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] In fact (chalcogen)semicarbazones with activities comparable to standard anticancer drugs, like cis-diammindichloridoplatinumIJII) (cisplatin, CDDP), have been developed. A few comprehensive comparative studies of (chalcogen)semicarbazones and their complexes pointed out the importance of the chalcogen donor atom identity for biological activity.…”
Section: Introductionmentioning
confidence: 99%
“…37,39,40 Selenosemicarbazones and their metal complexes have been an area of our particular interest for years. [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47]41,42 Research suggests that the mechanisms of cytotoxicity of these compounds may include the production of reactive oxygen species and oxidative stress in the complexes with 2-quinolinecarboxaldehyde selenosemicarbazone. 37 In the current study we used 8-quinolinecarboxaldehydebased (chalcogen)semicarbazones as ligands (Scheme 1), providing detailed spectroscopic and structural characterization (X-ray diffraction, XRD) of the novel cobalt complexes with oxygen and sulphur-based ligands.…”
Section: Introductionmentioning
confidence: 99%