2017
DOI: 10.1111/bph.13868
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Abstract: These novel PDE1 inhibitors induce vasodilation and lower BP, suggesting a potential use of these vasodilators in the treatment of hypertension and vasospasm.

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Cited by 25 publications
(27 citation statements)
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References 39 publications
(56 reference statements)
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“…Laursen et al . () similarly demonstrated ODQ‐sensitive relaxation to Lu AF58027 in rat mesenteric arteries pre‐contracted with U46619 and the selective α 1 ‐adrenergic receptor agonist, phenylephrine. Accordingly, PDE1 inhibition potentiated the relaxation induced by the sGC activator BAY 41‐2272, an effect that was abolished with PKG inhibition.…”
Section: Discussionmentioning
confidence: 78%
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“…Laursen et al . () similarly demonstrated ODQ‐sensitive relaxation to Lu AF58027 in rat mesenteric arteries pre‐contracted with U46619 and the selective α 1 ‐adrenergic receptor agonist, phenylephrine. Accordingly, PDE1 inhibition potentiated the relaxation induced by the sGC activator BAY 41‐2272, an effect that was abolished with PKG inhibition.…”
Section: Discussionmentioning
confidence: 78%
“…Taken together, our results suggest that PDE1 inhibition mediates relaxation predominantly through the cGMP/PKG pathway. However, the contribution of the AC/cAMP pathway cannot be completely dismissed; a recent study by (Laursen et al ., ) showed that the AC inhibitor, SQ22536, partially inhibited relaxation induced by Lu AF58027 in the rat mesenteric artery.…”
Section: Discussionmentioning
confidence: 95%
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