Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties

Muñoz-Escobar, Antonio; Ruíz-Baltazar, Álvaro de Jesús; Reyes-López, Simón Yobanny

doi:10.1177/1559325819869502

Cited by 30 publications

(34 citation statements)

References 21 publications

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“…The presence of this metal nanoparticles incremented the electrical charge, conductivity and viscosity on the solutions, resulting on an increase of the fibers diameter. The average diameters of PCL and PCL-CuONPs nanofibers were from 522±156 nm, 925±279 nm, 908±18 nm, 945±388 nm and 1082±329 nm for CuONPs contents of 0, 1, 10, 50 and 100 nM, respectively according previous data reported [15].…”

Section: Resultssupporting

confidence: 83%

“…However, there was noted only some variation in nanoparticle size. Most sizes of the particles ranged from 20 to 45 nm, and the average size was estimated at 35 nm for all concentrations according previous work [15]. Nanoparticle sizes were not directly proportional to the precursor salt concentration.…”

Section: Resultsmentioning

confidence: 72%

“…Synthesis of CuONPs was carried out by a non-aqueous chemical method using copper nitrate as precursor and gallic acid as reducing agent according to [15]. Initial concentrations of copper nitrate (0 mM, 25 mM, 50 mM, 100 mM and 200 mM) were added into a solution of 7:3 of DMF and THF respectively; and then it was placed under magnetic stirring were gallic acid (0.02 M) in DMF:THF solution was added dropwise.…”

Section: Copper Oxide Nanoparticles Preparationmentioning

confidence: 99%

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Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs)

Muñoz-Escobar

Reyes-López

2020

PLoS ONE

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The integration of metallic or ceramic nanoparticles in polymer matrices has improved the antimicrobial and antifungal behavior, resulting in the search for composites with increased bactericidal and antimycotic properties. A polycaprolactone fibers with copper oxide nanoparticles was prepared. Polycaprolactone-copper fibers (PCL-CuONPs) were prepared into two major steps in situ method: (a) Synthesis of CuO particles, then (b) incorporation of polycaprolactone to electrospun process. The first step is the reduction of Cu+2 ions by gallic acid in N,N-dimethylformamide and tetrahydrofuran solution with the simple addition of polycaprolactone in the solution for the second electrospun step. Raman spectra provide information about the nature of the copper oxide synthesized. There are three Raman peaks in the sample, at 294 and 581 cm-1 and a very broad band from 400 to 600 cm-1 which are characteristics bands for CuO. Scanning electron microscopy (TEM) revealed copper oxide nanoparticles with semispherical shapes with diameter 35 ±11 nm. Dynamic light scattering (DLS) analysis showed uniform CuONPs in a range of 88±11 nm. Scanning electron microscopy (SEM) of PCL-CuONps reveled fibers with diameters ranging from 925 to 1080 nm were successfully obtained by electrospinning technique. Orientation, morphology and diameter were influenced by the increment on CuONPs concentration, with the smaller diameter present in samples prepared from low concentrated solutions. The antimycotic applicability of the composite was evaluated to determine the antifungal activity in three species of the genus Candida (Candida albicans, Candida glabrata and Candida tropicalis). PCL-CuONPs exhibit a considerable antifungal effect on all species tested. The preparation of PCL-CuONPs was simple, fast and low-cost for practical application as an antifungal dressing.

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Section: Resultssupporting

confidence: 83%

Section: Resultsmentioning

confidence: 72%

Section: Copper Oxide Nanoparticles Preparationmentioning

confidence: 99%

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Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs)

Muñoz-Escobar

Reyes-López

2020

PLoS ONE

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“…Nanomaterials offer elevated surface area to volume ratio with lower usage of materials leading to be more efficient in most applications, nanocomposites, and nanoparticles (NPs) are demonstrated antibacterial properties against to Gram-positive and Gram-negative bacteria. 4 The search for novel biomaterials should also include antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

“…Silver nanoparticles were effective in killing a wide variety of bacterial pathogens involved in nosocomial infections such as Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Klebsiella oxytoca and Escherichia coli . 1 - 12 The mechanism that has been reported is through the damage caused by Ag + ions to the cell membranes of bacteria. The antibacterial efficacy of AgNPs is also known to depend on size, shape, dose, and time.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Hydroxyapatite-Ag Composite as Antimicrobial Agent

Silva-Holguín

Reyes-López

2020

Dose-Response

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Innovative and improved antimicrobial agents by nanotechnology are developed to control and mitigation of resistant microorganisms. Nanoparticles of metals or oxide metals be able to be toxic to bacteria, demonstrating biocidal behaviors at low concentrations. The integration of silver nanoparticles in ceramic matrices has enhanced the antimicrobial performance, resulting in the search for new composites with improved bactericidal properties. The aim of this study was to prepare and characterize hydroxyapatite-silver nanocomposite and evaluate its antimicrobial properties against various Gram-positive and negative bacteria related to drug-resistance infections. Hydroxyapatite nanopowders were produced by sol-gel and silver nanoparticles were synthesized by reduction of Ag+ions with the simple addition of gallic acid. Hydroxyapatite-silver composite (HAp-AgNPs) was prepared by adsorption of AgNPs at several concentrations. The results of UV–visible spectroscopy, dynamic light scattering, and transmission scanning electron microscopy revealed the existence of AgNPs with diameters around 6 nm. Scanning electron microscopy and energy dispersive X-ray spectroscopy corroborated the presence of silver disseminated over the surface of hydroxyapatite nanopowders. All HAp-AgNPs composites demonstrated excellent antibacterial effect even at lower silver concentration. HAp-AgNPs composites have a higher possibility for medical applications focused no the control of microorganisms with drug-resistance.

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Green synthesized AgNPs, CuONPs, and Ag‐CuO NCs to effective antibiofilm activities and their potential application in aquaculture

Manikandan,

Arumugam,

Abdul

et al. 2023

Applied Organom Chemis

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The expanded emergence of drug‐resistant microbes remains a concern to the scientific community in developing effective therapeutics. Approach of green chemistry based nanomaterials fabrication is in high demand, due to biocompatibility, non‐toxic, and high surface area that adheres more biomolecules on surface. Green fabricated silver nanoparticles (AgNPs), copper oxide nanoparticles (CuONPs), and silver–copper oxide nanocomposites (Ag‐CuO NCs) were characterized by fluorescence and Raman spectroscopy, field emission scanning electron microscopy (FE‐SEM) with energy‐dispersive X‐ray spectroscopy (EDX), and thermogravimetric (TG)/differential scanning calorimetry (DSC) analysis. Antibiofilm potential of green fabricated AgNPs, CuONPs, and Ag‐CuO NCs was tested against aquatic pathogenic microorganisms such as Aeromonas hydrophila, Pseudomonas aeruginosa, and Staphylococcus aureus. This present study deals with bacterial growth rate, biofilm inhibition, and antibiofilm architecture of AgNPs, CuONPs, and Ag‐CuO NCs under the visualization of confocal laser scanning electron microscopy (CLSM). The FE‐SEM technique was used to observe dense and compact structure (control without NPs treatment) with treatment of NPs that showed reduced amount of cell population in A. hydrophila, P. aeruginosa, and S. aureus. The effective antibiofilm inhibition of Ag‐CuO NCs was achieved by reducing micro‐colonies compared with AgNPs and CuONPs. The AgNPs, CuONPs, and Ag‐CuO NCs demonstrated antibiofilm properties against Gram‐negative and Gram‐positive bacteria, indicating a combinatorial effect of green fabricated NPs in combination with plant metabolites against pathogenic bacteria. As a result, aforementioned nano‐product merits further investigation in order to be used as a potent adjuvant therapy as antagonistic toward various bacterial diseases in aquaculture.

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Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties

Cited by 30 publications

References 21 publications

Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs)

Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs)

Synthesis of Hydroxyapatite-Ag Composite as Antimicrobial Agent

Green synthesized AgNPs, CuONPs, and Ag‐CuO NCs to effective antibiofilm activities and their potential application in aquaculture

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