2015
DOI: 10.1096/fj.14-268441
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Abstract: Local mediators orchestrate the host response to both sterile and infectious challenge and resolution. Recent evidence demonstrates that maresin sulfido‐conjugates actively resolve acute inflammation and promote tissue regeneration. In this report, we investigated self‐limited infectious exudates for novel bioactive chemical signals in tissue regeneration and resolution. By use of spleens from Escherichia coli infected mice, self‐resolving infectious exudates, human spleens, and blood from patients with sepsis… Show more

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Cited by 101 publications
(151 citation statements)
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References 31 publications
(83 reference statements)
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“…8e11 PCTR1, a new member of the protectin family of SPMs, is produced by human leukocytes and is highly abundant in lymphatic tissue. 6 In the present report, PCTR1 was synthesized from the protectin epoxide precursor intermediate that was recently prepared by total organic synthesis and thus validates the PCTR1 structural assignment, stereochemistry, and potent actions. We also investigated the role of PCTR1 during infection and herein report that PCTR1 is temporally regulated during self-limited inflammation and promotes the resolution of bacterial infection.…”
Section: Inflammation and Its Natural Resolution Are Host-protective supporting
confidence: 63%
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“…8e11 PCTR1, a new member of the protectin family of SPMs, is produced by human leukocytes and is highly abundant in lymphatic tissue. 6 In the present report, PCTR1 was synthesized from the protectin epoxide precursor intermediate that was recently prepared by total organic synthesis and thus validates the PCTR1 structural assignment, stereochemistry, and potent actions. We also investigated the role of PCTR1 during infection and herein report that PCTR1 is temporally regulated during self-limited inflammation and promotes the resolution of bacterial infection.…”
Section: Inflammation and Its Natural Resolution Are Host-protective supporting
confidence: 63%
“…3,4 During the resolution of acute inflammation, a novel genus of hostprotective mediators biosynthesized from essential fatty acids termed specialized pro-resolving mediators (SPMs) 2 and their bioactive peptide-conjugate pathways were recently identified as novel resolution mediators that control regeneration. 5,6 SPMs are enzymatically produced during the resolution of acute inflammation, promote the clearance of bacteria and apoptotic cells, counter regulate proinflammatory mediator production, and stimulate the resolution of inflammation. 2 These mediators include protectins (PDs), resolvins (Rvs), maresins, and lipoxins.…”
Section: Inflammation and Its Natural Resolution Are Host-protective mentioning
confidence: 99%
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