Novel predictor of pulmonary arterial hypertension: Monocyte to HDL cholesterol ratio

Abstract

Monocyte to HDL cholesterol ratio (MHR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) have been proposed as novel systemic inflammatory markers. The aim of this study was to explore the association between MHR, LMR and NLR with pulmonary arterial hypertension (PAH). The study is a single-center, retrospective Cross-sectional study. The study group consisted of 73 patients with PAH and the control group 77 participants without cardiac pathology as determined by echocardiography. On admission, blood sampling to calculate MHR, LMR, NLR, and detailed clinical data were obtained. According to the Pearson test, systolic pulmonary artery pressure (PAP) value Higher MHR, NLR and lower LMR that indicates an enhanced inflammation were significantly increased in patients with PAH when compared with controls. Compared to many other inflammatory markers, these markers are widely available. positively correlated with the MHR and NLR (r:.35, P < .001 and r:.33, P < .001, respectively), but negatively correlated with LMR (r: −.26, P = .001). After multivariate logistic regression analysis, MHR, LMR, and NLR remained as significant predictors of PAH (OR: 2.651, 95% CI: 1.227–5.755, P = .007; OR: 0.647, 95% CI:0.450–0.931, P = .005; OR: 1.350, 95% CI: 1.054–1.650 P = .030, respectively).

Monocyte/High-Density Lipoprotein Ratio as an Inflammatory Marker in Patients with Irritable Bowel Syndrome

“…For instance, investigations by Barbara et 20) examined MHR as a predictor of inflammation and oxidative stress in acute pulmonary embolism patients and its correlation with mortality. This expanding body of literature exploring the relationship between MHR and inflammatory disorders is continually growing, with some conditions, like fibromyalgia or depression, only recently being linked to inflammation (25,28) and other associated diseases, including inflammatory bowel diseases, cardiovascular diseases, and pulmonary arterial hypertension which are well-recognized as inflammatory (17,19,27). In the presented study, patients with IBS had significantly higher monocyte counts and lower HDL levels.…”

Serum ASGR2 level: an efficacy biomarker for balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension

“…In CTEPH patients, dysfunctional HDL-C is associated with RV structure, PVR and proinflammatory effects (18)(19)(20). HDL-C levels are associated with peripheral blood leukocytes, including neutrophils, lymphocytes, and monocytes (21). The monocyte-to-HDL ratio is a novel marker of systemic inflammation in PH patients (21).…”

“…HDL-C levels are associated with peripheral blood leukocytes, including neutrophils, lymphocytes, and monocytes (21). The monocyte-to-HDL ratio is a novel marker of systemic inflammation in PH patients (21). The current understanding of the impact of ASGR2 on HDL-C formation and conversion, as well as its role in lipid metabolism and lipid levels, is still uncertain.…”