Novel Potentiometric Sensor for Estimation of the Moxifloxacin in the Pharmaceutical Samples, Urine, and Serum

Abstract

An easy, simple and ecofriendly process for the estimation of moxifloxacin (MFN) in the pharmaceutical samples, serum and blood. The prepared sensors contained moxifloxacin–bromophenol blue as ionphore and, tris(2-ethylhexyl) phosphate, di-butyl phthalate and di-butyl phosphate as plasticizers. The electrodes based on di-n-butyl phthalate (DBPH), Tris (2-ethylhexyl) phosphate (TEHP), and di-butyl phosphate (DBP), gave slope 44.50, 56.86 and 46.38 mV/decade, respectively. The linear concentrations were 1×10-5 - 1×10-2, 5×10-5- 1×10-2 and 5×10-5 - 1×10-2 M with detection limits of 9.0×10-6, 4.7×10-5 and 4.9×10-5 M and a lifetime of 17, 39 and 12 days for electrodes based on DBPH, TEHP, and DBP, respectively. The best electrode was TEHP which gave the best results. The sensor that based on TEHP as plasticizer was better response and stability, it was used to estimate the moxifloxacin in pharmaceutical samples using single and multi-standard addition potentiometry.