Novel Potential Biomarkers for <i>Opisthorchis viverrini</i> Infection and Associated Cholangiocarcinoma

Aksorn, Nithikoon; Roytrakul, Sittiruk; Kittisenachai, Suthathip; Leelawat, Kawin; Chanvorachote, Pithi; Topanurak, Supachai; Hamano, Shinjiro; Lek-Uthai, Usa

doi:10.21873/invivo.11321

Cited by 11 publications

(8 citation statements)

References 44 publications

(31 reference statements)

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“…Авторы предлагают использовать массив дан-ных для идентификации диагностических маркеров, в том числе для оценки интенсивности инвазии. В рамках другой работы проведено исследование O. viverrini, обнаружено три специфичных белкапотенциальных маркера O. viverrini [99]. Проведен протеомный анализ S. mekongi вместе с их экскреторно-секреторным белковым составом [100], протеомная скрининговая оценка рекомбинантных антигенов яиц для определения низкоинтенсивной степени инвазии S. mansoni [30].…”

Section: омиксные технологииunclassified

Foresight in the diagnosis of trematodiasis: innovations versus routine methods

et al. 2023

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Aim. To analyze modern methods for the diagnosis of trematodiasis in experimental and epidemiological studies.Trematodiasis is a group of common parasitic diseases that are a socially sensitive health problem worldwide. According to World Health Organization, more than 250 million people are affected by trematode infections globally. The most common types of human trematode infections are diseases caused by Schistosoma, Fasciola, Clonorchis, and Opisthorchis pathogens. Diagnosis of trematodiasis is often multistage and includes identification of disease symptoms, analysis of medical history, and use of various laboratory tests. Clinical presentation of parasitic infections often varies, making a definitive diagnosis difficult. Various tools are used to diagnose trematode infections: epidemiological criteria, laboratory tests (complete blood count and blood biochemistry, serological methods), instrumental methods (abdominal X-ray and ultrasound), and parasitological techniques, which often have insufficient sensitivity and specificity. Therefore, development of modern and effective non-invasive methods for detection of trematode infections with high sensitivity and specificity, including screening in endemic regions, is relevant.The present review analyzes the results of 90 clinical trials and experimental studies on the diagnosis of trematode infections using the PubMed search engine and the eLibrary database. The review analyzes original articles published from January 1, 2015 to December 31, 2021.Most studies confirm that the absence of a standard diagnostic approach highlights obvious convenience of utilizing a combined approach to reliable diagnosis of trematodiasis. An adequate combination of different diagnostic tests makes it possible to diagnose the disease correctly, devise a correct treatment and follow-up strategy, and organize preventive measures.

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Section: омиксные технологииunclassified

Foresight in the diagnosis of trematodiasis: innovations versus routine methods

et al. 2023

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“…Opisthorchis viverrini infection is also one of the factors causing CCA [ 139 ]. According to the study of Aksorn et al, immunoglobulin heavy chain, translocated in liposarcoma (TLS), Visual System Homeobox 2 (VSX2) and an unnamed protein product, can be used to distinguish the CCA associated with liver fluke infection, but their diagnostic performance is not elaborated [ 140 ].…”

Section: Search For Cca Diagnosis Biomarkers In Human Bile At Protein...mentioning

confidence: 99%

Diagnosis Biomarkers of Cholangiocarcinoma in Human Bile: An Evidence-Based Study

Bao

Liu

Chen

et al. 2022

Cancers

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Cholangiocarcinoma (CCA) is a multifactorial malignant tumor of the biliary tract, and the incidence of CCA is increasing in recent years. At present, the diagnosis of CCA mainly depends on imaging and invasive examination, with limited specificity and sensitivity and late detection. The early diagnosis of CCA always faces the dilemma of lacking specific diagnostic biomarkers. Non-invasive methods to assess the degree of CAA have been developed throughout the last decades. Among the many specimens looking for CCA biomarkers, bile has gotten a lot of attention lately. This paper mainly summarizes the recent developments in the current research on the diagnostic biomarkers for CCA in human bile at the levels of the gene, protein, metabolite, extracellular vesicles and volatile organic compounds.

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“…Aksorn et al also recognized novel potential biomarkers that are associated with these events in CCA. These candidates include immunoglobulin heavy chain, translocated in liposarcoma (TLS) and visual system homeobox 2 (VSX2) [ 61 ]. There are many typical and classic markers in CCA, including KRAS , TP53 , PROM1 , CTGF , VIM , DKK1 , SOX2 , SOX17 , MUC1 , PTEN , PTPN14 , c-Met , EGFR , VEGR , CD44 and CDH1 [ 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 ], but this review specifically focuses on novel evidence from the past five years.…”

Section: Canonical Pathways and Key Drivers Of The Transcriptomementioning

confidence: 99%

Omics-Based Platforms: Current Status and Potential Use for Cholangiocarcinoma

et al. 2020

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Cholangiocarcinoma (CCA) has been identified as a highly malignant cancer that can be transformed from epithelial cells of the bile duct, including intrahepatic, perihilar and extrahepatic. High-resolution imaging tools (abdominal ultrasound, computed tomography and percutaneous transhepatic cholangial drainage) are recruited for diagnosis. However, the lack of early diagnostic biomarkers and treatment evaluation can lead to serious outcomes and poor prognosis (i.e., CA19-9, MUC5AC). In recent years, scientists have established a large number of omics profiles to reveal underlying mechanisms and networks (i.e., IL-6/STAT3, NOTCH). With these results, we achieved several genomic alteration events (i.e., TP53mut, KRASmut) and epigenetic modifications (i.e., DNA methylation, histone modification) in CCA cells and clinical patients. Moreover, we reviewed candidate gene (such as NF-kB, YAP1) that drive gene transcription factors and canonical pathways through transcriptomics profiles (including microarrays and next-generation sequencing). In addition, the proteomics database also indicates which molecules and their directly binding status could trigger dysfunction signatures in tumorigenesis (carbohydrate antigen 19-9, mucins). Most importantly, we collected metabolomics datasets and pivotal metabolites. These results reflect the pharmacotherapeutic options and evaluate pharmacokinetic/pharmacodynamics in vitro and in vivo. We reversed the panels and selected many potentially small compounds from the connectivity map and L1000CDS2 system. In this paper, we summarize the prognostic value of each candidate gene and correlate this information with clinical events in CCA. This review can serve as a reference for further research to clearly investigate the complex characteristics of CCA, which may lead to better prognosis, drug repurposing and treatment strategies.

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Novel Potential Biomarkers for Opisthorchis viverrini Infection and Associated Cholangiocarcinoma

Abstract: Abstract. Background

Cited by 11 publications

References 44 publications

Foresight in the diagnosis of trematodiasis: innovations versus routine methods

Foresight in the diagnosis of trematodiasis: innovations versus routine methods

Diagnosis Biomarkers of Cholangiocarcinoma in Human Bile: An Evidence-Based Study

Omics-Based Platforms: Current Status and Potential Use for Cholangiocarcinoma

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