Abstract:Background and Purpose: TREK-1 (TWIK-related potassium channel-1) is a
subunit of the two-pore domain potassium (K2p) channel and is widely
expressed in the brain. TREK-1 knockout mice were shown to have
antidepressant-like effects, providing evidence for the channel’s
potential as a therapeutic target. However, currently there is no good
pharmacological inhibitor specifically targeting TREK-1 containing K2p
channels that also displays similar antidepressant-like effects.
Experimental Approach: We sought to fi… Show more
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