Novel pH-responsive multilayer magnetic nanoparticles for controlled drug delivery

Motevalizadeh, Seyed Farshad; Khoobi, Mehdi; Babanejad, Niloofar; Mohit, Elham; Dehghankelishadi, Pouya; Javar, Hamid Akbari; Dorkoosh, Farid Abedin; Faramarzi, Mohammad Ali; Shafiee, Abbas

doi:10.1007/s13738-016-0882-2

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…However, this drug has side effects such as short half-life and low solubility in aqueous solutions that limit its use in clinic applications . So far, magnetic iron oxide NPs coated with a variety of polymers have been reported as nanocarriers for anticancer drug delivery. − Among these studies, targeted drug delivery with various targeting agents has been done, for instance, targeting with an external magnetic field , or folic acid . It is well known that anticancer targeted drug delivery is the most important factor in the theranostic area, so in this study, a targeted drug delivery system for nanoparticles loaded with DOX has been developed.…”

Section: Introductionmentioning

confidence: 99%

Cell-Penetrating Peptidic GRP78 Ligand-Conjugated Iron Oxide Magnetic Nanoparticles for Tumor-Targeted Doxorubicin Delivery and Imaging

Hasani

Jafari

Javar

et al. 2023

ACS Appl. Bio Mater.

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Although chemotherapy is regarded as an essential option in cancer treatment, it is still far from being perfect. Inadequate tumor drug concentration and systemic toxicity along with broad biodistribution have diminished the utility of chemotherapy. Tumor-targeting peptide-conjugated multifunctional nanoplatforms have emerged as an effective strategy for site-directed tumor tissues in cancer treatment and imaging. Herein, Pep42-targeted iron oxide magnetic nanoparticles (IONPs) functionalized with β-cyclodextrin (ßCD) containing doxorubicin (DOX) (Fe3O4-ßCD-Pep42-DOX) were successfully developed. The physical effects of the prepared NPs were characterized by employing various techniques. Transmission electron microscopy (TEM) images disclosed that the developed Fe3O4-ßCD-Pep42-DOX nanoplatforms had a spherical morphology and a core–shell structure with a size of nearly 17 nm. Fourier transform infrared (FT-IR) spectroscopy showed that β-cyclodextrin, DOX, and Pep42 molecules were successfully loaded on the IONPs. In vitro cytotoxicity analysis revealed that the fabricated multifunctional Fe3O4-ßCD-Pep42 nanoplatforms possessed excellent biosafety toward BT-474, MDA-MB468 (cancerous cells), and MCF10A normal cells, while Fe3O4-ßCD-Pep42-DOX exhibited great cancer cell killing ability. The high cellular uptake along with intracellular trafficking of Fe3O4-ßCD-Pep42-DOX highlights the usefulness of the Pep42-targeting peptide. In vivo results strongly supported the in vitro results, i.e., significant tumor size reduction was observed by single-dose injection of Fe3O4-ßCD-Pep42-DOX into tumor-bearing mice. Interestingly, in vivo MR imaging (MRI) of Fe3O4-ßCD-Pep42-DOX revealed T 2 contrast improvement in the tumor cells and therapeutic ability in cancer theranostics. Taken together, these findings provided strong evidence for the potential capability of Fe3O4-ßCD-Pep42-DOX as a multifunctional nanoplatform in cancer therapy and imaging and opens up a new avenue of research in this area.

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Section: Introductionmentioning

confidence: 99%

Cell-Penetrating Peptidic GRP78 Ligand-Conjugated Iron Oxide Magnetic Nanoparticles for Tumor-Targeted Doxorubicin Delivery and Imaging

Hasani

Jafari

Javar

et al. 2023

ACS Appl. Bio Mater.

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“…In the design of different drug delivery systems, development of sustained-release formulations is of high importance; nevertheless, various defects attributed to sustained delivery systems consisted of high initial bursts release following minimal release and low entrapment efficiency should be solved [13]. In addition, the polymers used in the design of intelligent drug delivery systems should not produce any toxic compound after metabolisation [14][15][16]; therefore, in order to address this goal, applying natural materials such as vegetable oils instead of petroleum-based materials in drug delivery systems are necessitated [17].…”

Section: Introductionmentioning

confidence: 99%

Sustained delivery of olanzapine from sunflower oil‐based polyol‐urethane nanoparticles synthesised through a cyclic carbonate ring‐opening reaction

Babanejad

Nabid

Farhadian

et al. 2019

IET nanobiotechnol.

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The forefront horizon of biomedical investigations in recent decades is parcelling-up and delivery of drugs to achieve controlled/targeted release. In this regard, developing green-based delivery systems for a spatiotemporal controlling therapeutic agent have drawn a lot of attention. A facile route based on cyclic carbonate ring-opening reaction has been utilised to synthesise a bio-based polyol-containing urethane bond [polyol-urethane (POU)] as a nanoparticulate drug delivery system of olanzapine in order to enhance its bioavailability. After characterisation, the nanoparticles were also estimated for in vitro release, toxicity, and pharmacokinetic studies. As olanzapine has shown poor bioavailability and permeability in the brain, the sustained release of olanzapine from the designed carriers could enhance pharmacokinetic effectiveness. POU in the aqueous solution formed micelles with a hydrophobic core and embedded olanzapine under the influence of its hydrophobic nature. Drug release from the nanoparticles (90 ± 0.43 nm in diameter) indicated a specific pattern with initial burst release, and then a sustained release behaviour (82 ± 3% after 168 h), by the Higuchi-based release mechanism. Pharmacokinetics assessments of POU-olanzapine nanoparticles were carried in male Wistar rats through intravenous administration. The obtained results paved a way to introduce the POU as an efficient platform to enhance the bioavailability of olanzapine in therapeutic methods.

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“…Chen et al [10] used the two-component initiating system of the mercapto group and benzoyl peroxide (BPO) to initiate the polymerization of HEMA grafted on SiO 2 to study the adsorption of quercetin by SiO 2 -g-PHEMA. Motevalizadeh et al [11] used MPTMS to modify MNP, the mercapto group, and butylactam and formed a two-component initiating system to initiate the copolymerization of St and AL, and studied the rate of drug delivery control. Survant et al [12] modified organoclay by MPTMS and initiated free radical polymerization on its surface to prepare polystyrene-organoclay composites.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Thermal Decomposition Kinetics of Novel Silane Coupling Agent with Mercapto Group

Wang

et al. 2019

Journal of Nanomaterials

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Using carbon disulfide and 3-aminopropyltriethoxysilane as raw materials, a novel silane coupling agent with a terminal group was synthesized for the first time. The compound was synthesized in two steps in ethanol water solvent under the action of the catalyst triethylamine and a sulfhydryl-protecting agent. The product was characterized by FT-IR, 1H NMR, and mass spectra to determine and prove its structure. The best experimental scheme was explored by a single factor experiment: a thiol-protecting agent selected iodomethane, the total reaction time was 2 hours, the two-step reaction temperature was 15°C and 10°C, respectively, and ncarbon disulfide: n3−aminopropyl three ethoxysilane=1.4:1. Under these conditions, the product yield was up to 74.28%. Secondly, using the nonisothermal decomposition method, the thermal stability and thermal decomposition enthalpy of a thiohydrazide-iminopropyltriethoxysilane coupling agent were measured by a differential scanning calorimeter (DSC). Thereby, the thermal decomposition kinetic parameters and kinetic equations of the thiohydrazide-iminopropyltriethoxysilane coupling agent were derived.

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Novel pH-responsive multilayer magnetic nanoparticles for controlled drug delivery

Cited by 3 publications

References 28 publications

Cell-Penetrating Peptidic GRP78 Ligand-Conjugated Iron Oxide Magnetic Nanoparticles for Tumor-Targeted Doxorubicin Delivery and Imaging

Cell-Penetrating Peptidic GRP78 Ligand-Conjugated Iron Oxide Magnetic Nanoparticles for Tumor-Targeted Doxorubicin Delivery and Imaging

Sustained delivery of olanzapine from sunflower oil‐based polyol‐urethane nanoparticles synthesised through a cyclic carbonate ring‐opening reaction

Preparation and Thermal Decomposition Kinetics of Novel Silane Coupling Agent with Mercapto Group

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