Novel P2X₇ Receptor Antagonists.

Abstract

Novel P2X 7 Receptor Antagonists. -The synthesis and pharmacological evaluation of a series of novel cyclic imides that are potent P2X 7 receptor antagonists is disclosed. -(ALCARAZ*, L.; et al.; Bioorg. Med. Chem. Lett. 13 (2003) 22, 4043-4046; Dep. Med. Chem., Astra Charnwood, Loughborough, Leicestershire LE11 5RH, UK; Eng.) -H. Haber

Gravitational collapse inf(R) theories

“…Although there are many possible origins for this component [2], DM is usually assumed to be in the form of thermal relics that naturally freeze-out with the right abundance in many extensions of the standard model of particles [3]. Future experiments will be able to discriminate among the large number of candidates and models, such as direct and indirect detection designed explicitly for their search [4], or even at high energy colliders, where they could be produced [5].…”

Reliability of Monte Carlo event generators for gamma-ray dark matter searches

“…In order to confirm its nature, DM searches have followed different directions. On the one hand, DM particles can be produced in laboratory experiments such as high-energy particle colliders [3]. On the other hand, local DM can be detected in a direct or indirect way [4][5][6][7][8][9].…”

Measurement of the cosmic ray hadron spectrum up to 30 TeV at mountain altitude: the primary proton spectrum

“…A precise knowledge of such spectra is of particular importance to interpret the observational data from muon and neutrino detectors deep underground [12]. The measurement of the primary proton spectrum has been performed by means of satellite and balloon borne experiments [13][14][15][16][17][18][19][20][21][22][23][24][25][26] and indirectly derived by using ground based detectors [27][28][29][30]. In the region of tens of TeV, however, direct measurements lack statistics and moreover their energy determinations are not calorimetric and depend on the interaction parameters and their fluctuations.…”