Novel nucleotide variants in SLA-DOB and CD4 are associated with immune traits in pregnant sows

Zhang, Fengxia; Yang, Ting; Hong, Ai; Zhai, Lichao; Tan, Zhen; Wang, Yuan; Xing, Kai; Zhao, Xitong; Wang, Zhiquan; Yu, Ying; Wang, Chuduan

doi:10.1016/j.gene.2019.04.057

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…The SLA-DOB is involved in the epitope loading of MHC Class II molecules and is associated with both CD4 + and CD8 + T-cells. In addition, SLA-DOB shows a highly significant association with immunoglobulin G and PRRSV-specific antibody response [ 57 ]. TAP2 is a transporter that is associated with antigen processing [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses

Sanglard

Huang²,

Gray³

et al. 2021

Genet Sel Evol

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Background The possibility of using antibody response (S/P ratio) to PRRSV vaccination measured in crossbred commercial gilts as a genetic indicator for reproductive performance in vaccinated crossbred sows has motivated further studies of the genomic basis of this trait. In this study, we investigated the association of haplotypes and runs of homozygosity (ROH) and heterozygosity (ROHet) with S/P ratio and their impact on reproductive performance. Results There was no association (P-value ≥ 0.18) of S/P ratio with the percentage of ROH or ROHet, or with the percentage of heterozygosity across the whole genome or in the major histocompatibility complex (MHC) region. However, specific ROH and ROHet regions were significantly associated (P-value ≤ 0.01) with S/P ratio on chromosomes 1, 4, 5, 7, 10, 11, 13, and 17 but not (P-value ≥ 0.10) with reproductive performance. With the haplotype-based genome-wide association study (GWAS), additional genomic regions associated with S/P ratio were identified on chromosomes 4, 7, and 9. These regions harbor immune-related genes, such as SLA-DOB, TAP2, TAPBP, TMIGD3, and ADORA. Four haplotypes at the identified region on chromosome 7 were also associated with multiple reproductive traits. A haplotype significantly associated with S/P ratio that is located in the MHC region may be in stronger linkage disequilibrium (LD) with the quantitative trait loci (QTL) than the previously identified single nucleotide polymorphism (SNP) (H3GA0020505) given the larger estimate of genetic variance explained by the haplotype than by the SNP. Conclusions Specific ROH and ROHet regions were significantly associated with S/P ratio. The haplotype-based GWAS identified novel QTL for S/P ratio on chromosomes 4, 7, and 9 and confirmed the presence of at least one QTL in the MHC region. The chromosome 7 region was also associated with reproductive performance. These results narrow the search for causal genes in this region and suggest SLA-DOB and TAP2 as potential candidate genes associated with S/P ratio on chromosome 7. These results provide additional opportunities for marker-assisted selection and genomic selection for S/P ratio as genetic indicator for litter size in commercial pig populations.

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Section: Discussionmentioning

confidence: 99%

Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses

Sanglard

Huang²,

Gray³

et al. 2021

Genet Sel Evol

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show abstract

“…The SLA-DOB is involved in the epitope loading of MHC Class II molecules and is associated with both CD4 + and CD8 + T-cells. In addition, SLA-DOB shows a highly significant association with Immunoglobulin G and PRRSV-specific antibody response (Zhang et al, 2019). TAP2 is a transporter that is associated with antigen processing (Rui, 2011).…”

Section: Haplotype-based Gwas -Approachmentioning

confidence: 99%

Genetic and phenotypic indicator traits for reproductive performance in commercial sows

Sanglard¹,

Leticia²

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Novel DNA methylation markers of PRRSV-specific antibodies and their intergenerational transmission from pregnant sows to piglets

Zhang

Chen

Yang

et al. 2021

Gene

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Novel nucleotide variants in SLA-DOB and CD4 are associated with immune traits in pregnant sows

Cited by 3 publications

References 46 publications

Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses

Further host-genomic characterization of total antibody response to PRRSV vaccination and its relationship with reproductive performance in commercial sows: genome-wide haplotype and zygosity analyses

Genetic and phenotypic indicator traits for reproductive performance in commercial sows

Novel DNA methylation markers of PRRSV-specific antibodies and their intergenerational transmission from pregnant sows to piglets

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