2020 DOI: 10.20944/preprints202009.0015.v1 View full text Preprint
Mayanka Awasthi, Kumari Sushmita, Manish Kaushik, Peeyush Ranjan, Suneel Kateriya

Abstract: Light-gated ion channel and ion pump rhodopsins are widely used as optogenetic tools and these can control the electrically excitable cells as: (1) they are a single-component system i.e., their sensor and effector functions are encoded by the 7-transmembrane domains and (2) they show fast kinetics with small dark-thermal recovery time. In cellular signaling, a signal receptor, modulator and effector components are involved for attaining synchronous multicomponent regulation. Optical modulation of this network…

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