Novel Markers for Diagnosis and Prognosis of Oral Intraepithelial Neoplasia

Celetti, Angela; Merolla, Francesco; Luise, Chiara; Siano, Maria; Staibano, Stefania

doi:10.5772/30981

Cited by 3 publications

(3 citation statements)

References 177 publications

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“…OSCC or OC is a multistep process originating from epithelial cells by progressive accumulation of genetic and epigenetic alterations. The histological changes that occur during the carcinogenesis begin with atypical squamous cell hyperplasia to carcinoma in situ (CIS) through stages of dysplasia [290]. The molecular events associated with alterations in different protein coding genes during the development of OC are extensively studied [290].…”

Section: Ncrnas In Oral Cancer Progressionmentioning

confidence: 99%

“…The histological changes that occur during the carcinogenesis begin with atypical squamous cell hyperplasia to carcinoma in situ (CIS) through stages of dysplasia [290]. The molecular events associated with alterations in different protein coding genes during the development of OC are extensively studied [290]. However, the role of ncRNAs is not well-studied in this regard.…”

Section: Ncrnas In Oral Cancer Progressionmentioning

confidence: 99%

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Non-Coding RNAs in Oral Cancer: Emerging Roles and Clinical Applications

Dey,

Biswas,

Manoj Appadan

et al. 2023

Cancers

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Oral cancer (OC) is among the most prevalent cancers in the world. Certain geographical areas are disproportionately affected by OC cases due to the regional differences in dietary habits, tobacco and alcohol consumption. However, conventional therapeutic methods do not yield satisfying treatment outcomes. Thus, there is an urgent need to understand the disease process and to develop diagnostic and therapeutic strategies for OC. In this review, we discuss the role of various types of ncRNAs in OC, and their promising clinical implications as prognostic or diagnostic markers and therapeutic targets. MicroRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA), PIWI-interacting RNA (piRNA), and small nucleolar RNA (snoRNA) are the major ncRNA types whose involvement in OC are emerging. Dysregulated expression of ncRNAs, particularly miRNAs, lncRNAs, and circRNAs, are linked with the initiation, progression, as well as therapy resistance of OC via modulation in a series of cellular pathways through epigenetic, transcriptional, post-transcriptional, and translational modifications. Differential expressions of miRNAs and lncRNAs in blood, saliva or extracellular vesicles have indicated potential diagnostic and prognostic importance. In this review, we have summarized all the promising aspects of ncRNAs in the management of OC.

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Section: Ncrnas In Oral Cancer Progressionmentioning

confidence: 99%

Section: Ncrnas In Oral Cancer Progressionmentioning

confidence: 99%

Non-Coding RNAs in Oral Cancer: Emerging Roles and Clinical Applications

Dey,

Biswas,

Manoj Appadan

et al. 2023

Cancers

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“…Stem cells are implicated in the origin of cancer. These cells can acquire mutations and epigenetic changes that can favor the progression to malignancy (Celetti et al, 2012). Many solid malignancies, including the OSCC, contain a small population of tumorigenic stem cells.…”

Section: Introductionmentioning

confidence: 99%

Stem cell markers expression evaluation in Oral Squamous Cell Carcinoma

Cadilho

Lyra

Lima

et al. 2021

RSD

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Oral carcinogenesis is a highly complex process. Molecular studies demonstrate that some oral cancers progress from pre-neoplastic lesions. Cancer stem cells (CSCs), a small cellular group within the tumor, have currently received much attention by its self-renewal and tumor differentiation ability. It is considered that CSCs may be responsible for the relapse and metastasis of cancer. CSCs have been reported to express common embryonic stem cells markers such as Nestin and Nanog. The aim of the present study was to identify the presence of Nestin and Nanog markers in patients with oral squamous cell carcinoma (OSCC). Nine samples were collected from patients diagnosed with OSCC and two healthy oral mucosa were used as control. The markers expression in nine OSCC was determined by end-point PCR. The OSCC population analyzed was mostly composed of black and white males, with a mean age of 70.6 years, that reported alcohol and tobacco consumption. Nestin and Nanog stem cell markers were expressed in all OSCCs and normal samples analyzed. As these two markers have already been related to the mechanism of metastasis and relapses in cancer, its expression determination could help to understand the aggressive and invasive nature of OSCC.

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