J. Neurosci. Res. volume 86, issue 4, P904-909 2008 DOI: 10.1002/jnr.21543 View full text
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Klaus van Leyen, Ken Arai, Guang Jin, Victor Kenyon, Bettina Gerstner, Paul A. Rosenberg, Theodore R. Holman, Eng H. Lo

Abstract: AbstractThe lipid-metabolizing enzyme 12/15-lipoxygenase (12/15-LOX) mediates cell death resulting from oxidative stress in both neurons and oligodendrocytes. Specifically, it may contribute to the pathophysiology of stroke and Alzheimer's and Parkinson's diseases. We report here that two of three specific 12/15-LOX inhibitors, derived from a virtual screen by computer modeling and validated by inhibition of recombinant human 15-LOX in vitro, are able to rescue both neuronal as well as oligodendroglial cells …

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