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Cited by 15 publications
(13 citation statements)
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“…CQ and memantine share the feature of being lipophilic, suggesting that they act via incorporation into the lipid bilayer [17,35,36]. When the surface membrane is exposed to these compounds, their protonated groups can be attracted to the gate within MEP-induced channel, whereas the lipophilic ones would strongly bind to the hydrophobic groups in the channel lining, thereby effectively preventing access of ions to the pore of the channel.…”
Section: Discussionmentioning
confidence: 99%
“…CQ and memantine share the feature of being lipophilic, suggesting that they act via incorporation into the lipid bilayer [17,35,36]. When the surface membrane is exposed to these compounds, their protonated groups can be attracted to the gate within MEP-induced channel, whereas the lipophilic ones would strongly bind to the hydrophobic groups in the channel lining, thereby effectively preventing access of ions to the pore of the channel.…”
Section: Discussionmentioning
confidence: 99%
“…1,2 Some of these lipofection systems, especially Fugene6t, however, are not cGMP-conform. 3 For these reasons, we tested our cGMP-quality lipids, CCQ22 and CCQ32, 3 in breast and ovarian cancer substrates.…”
Section: Discussionmentioning
confidence: 99%
“…3 For FACS analysis we used pEGFP-C1 (Clontech, Heidelberg, Germany). The control plasmid pRc/CMV was purchased from Invitrogen, Groningen, The Netherlands.…”
Section: Plasmid Dnasmentioning
confidence: 99%
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