Novel isoquinoline derivatives from isochromen-1,3-dione

Novel Synthesis of Some Phthalazinone Derivatives

“…In our laboratories, it has been found that when a mixture of isatin and dimethyl homophthalate was treated in absolute methanol in the presence of sodium methoxide, the previously reported 30,31 half ester 1 or six-membered lactone (isocoumarin) 2 have not been isolated, but the lactone 3 was obtained as the sole product (Eq. 1).…”

Novel Synthesis of Some Phthalazinone Derivatives

“…In our laboratories, it has been found that when a mixture of isatin and dimethyl homophthalate was treated in absolute methanol in the presence of sodium methoxide, the previously reported 30,31 half ester 1 or six-membered lactone (isocoumarin) 2 have not been isolated, but the lactone 3 was obtained as the sole product (Eq. 1).…”

Synthesis of novel quinazolinone and fused quinazolinones

“…The molarity of amines and reaction time [38] are not the sole factors necessary for cyclization of the anilide derivatives to the corresponding 3-substituted quinazoline derivatives. However, the reaction of 1 with benzidine in nbutanol furnished the cyclized product 10.…”

Pd‐Catalyzed Cross‐Dehydrogenative Coupling of 3‐Benzoyl Substituted Coumarins: Efficient Access to Indeno[2,1‐c]chromene‐6,7‐diones

“…To our surprise, only a few examples of syntheses of such coumarin‐fused indanone heterocycles are known in the literatures. In 2008, EI‐Azm's group [10] disclosed that homophthalates condensed with ortho‐ chlorobenzaldehyde followed by cyclization in the presence of acid to access indeno[1,2‐ c ]chromen‐11(6 H )‐one derivative. Last year, Yang and co‐workers [9] developed a method to synthesize indeno[2,1‐ c ]chromene‐6,7‐dione derivative by a 5‐step process employing 2‐(4‐diethylamino‐2hydroxybenzoyl)benzoic acid as a starting material (Scheme 1).…”

Novel Synthesis of Some Phthalazinone Derivatives

“…In our laboratories, it has been found that when a mixture of isatin and dimethyl homophthalate was treated in absolute methanol in the presence of sodium methoxide, the previously reported 30,31 half ester 1 or six-membered lactone (isocoumarin) 2 have not been isolated, but the lactone 3 was obtained as the sole product (Eq. 1).…”

Synthesis of novel quinazolinone and fused quinazolinones

“…The molarity of amines and reaction time [38] are not the sole factors necessary for cyclization of the anilide derivatives to the corresponding 3-substituted quinazoline derivatives. However, the reaction of 1 with benzidine in nbutanol furnished the cyclized product 10.…”

Pd‐Catalyzed Cross‐Dehydrogenative Coupling of 3‐Benzoyl Substituted Coumarins: Efficient Access to Indeno[2,1‐c]chromene‐6,7‐diones

“…To our surprise, only a few examples of syntheses of such coumarin‐fused indanone heterocycles are known in the literatures. In 2008, EI‐Azm's group [10] disclosed that homophthalates condensed with ortho‐ chlorobenzaldehyde followed by cyclization in the presence of acid to access indeno[1,2‐ c ]chromen‐11(6 H )‐one derivative. Last year, Yang and co‐workers [9] developed a method to synthesize indeno[2,1‐ c ]chromene‐6,7‐dione derivative by a 5‐step process employing 2‐(4‐diethylamino‐2hydroxybenzoyl)benzoic acid as a starting material (Scheme 1).…”

Novel Synthesis of Some Phthalazinone Derivatives

“…In our laboratories, it has been found that when a mixture of isatin and dimethyl homophthalate was treated in absolute methanol in the presence of sodium methoxide, the previously reported 30,31 half ester 1 or six-membered lactone (isocoumarin) 2 have not been isolated, but the lactone 3 was obtained as the sole product (Eq. 1).…”

Synthesis of novel quinazolinone and fused quinazolinones

“…The molarity of amines and reaction time [38] are not the sole factors necessary for cyclization of the anilide derivatives to the corresponding 3-substituted quinazoline derivatives. However, the reaction of 1 with benzidine in nbutanol furnished the cyclized product 10.…”

Pd‐Catalyzed Cross‐Dehydrogenative Coupling of 3‐Benzoyl Substituted Coumarins: Efficient Access to Indeno[2,1‐c]chromene‐6,7‐diones

“…To our surprise, only a few examples of syntheses of such coumarin‐fused indanone heterocycles are known in the literatures. In 2008, EI‐Azm's group [10] disclosed that homophthalates condensed with ortho‐ chlorobenzaldehyde followed by cyclization in the presence of acid to access indeno[1,2‐ c ]chromen‐11(6 H )‐one derivative. Last year, Yang and co‐workers [9] developed a method to synthesize indeno[2,1‐ c ]chromene‐6,7‐dione derivative by a 5‐step process employing 2‐(4‐diethylamino‐2hydroxybenzoyl)benzoic acid as a starting material (Scheme 1).…”