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Cited by 49 publications
(59 citation statements)
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References 36 publications
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“…The physical properties of ISCOM adjuvants contribute to antigen stability, reduce the haemolytic effects associated with saponins, interact with dendritic cells (DCs) and enhance cross-presentation of the incorporated antigen, generating both antibody and CD4 + and CD8 + T cell responses 2 , 29 , 31 , 32 . In summary, ISCOM and ISCOMATRIX TM vaccines are known to induce long-lasting antibody responses, a balanced Th1/Th2 response, and generation of cytotoxic T lymphocytes in mice 33 , 34 and humans 13 , 15 , 35 .…”
Section: Introductionmentioning
confidence: 99%
“…The physical properties of ISCOM adjuvants contribute to antigen stability, reduce the haemolytic effects associated with saponins, interact with dendritic cells (DCs) and enhance cross-presentation of the incorporated antigen, generating both antibody and CD4 + and CD8 + T cell responses 2 , 29 , 31 , 32 . In summary, ISCOM and ISCOMATRIX TM vaccines are known to induce long-lasting antibody responses, a balanced Th1/Th2 response, and generation of cytotoxic T lymphocytes in mice 33 , 34 and humans 13 , 15 , 35 .…”
Section: Introductionmentioning
confidence: 99%
“…Mucosal delivered vaccines have the advantage of not being affected by maternal antibody interference, being able to induce a response in neonates less than 7 days of age, and priming the common mucosal immune system (for example, oral coronavirus vaccination would provide specific coronavirus immunity to the respiratory mucosa). 67 The use of novel adjuvants with parenteral vaccines 76 that induce mucosal responses in addition to novel mucosal delivered adjuvants will also enhance enteric immunity. 77 The area with the most opportunity that is also the least characterized is the use of direct-fed microbials to enhance enteric immunity and animal health while reducing antimicrobial usage.…”
Section: Maximizing Enteric Immunity: Passive Immunity Vaccines Andmentioning
confidence: 99%
“…Steroidal compounds are less common and usually found among the monocotyledons, while triterpenoid saponins are more widely distributed and typical of the dicotyledons. Many studies have illustrated the beneficial effects of these metabolites on blood cholesterol levels, cancer, and stimulation of the immune system [29,127,128]. The soybean saponins possess antiinflammatory properties as they are able to inhibit the release of MCP-1 and other pro-inflammatory mediators by LPS-stimulated peritoneal macrophages in a dose-dependent manner [129].…”
Section: Saponinsmentioning
confidence: 99%