2018
DOI: 10.1089/scd.2018.0118
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Abstract: Adult tissues are thought to harbor two populations of "dormant" and "actively dividing" stem cells. Quiescent stem cells undergo rare asymmetric cell divisions (ACDs) through which they self-renew and give rise to tissue-committed "progenitors" of distinct fate and "progenitors" in turn undergo symmetric cell divisions (SCDs) and clonal expansion. However, quiescent stem cells have not been demonstrated in adult tissues such as skin, testis, liver, and brain. After surgical removal of part of liver and pancre… Show more

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Cited by 41 publications
(30 citation statements)
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“…With the support and regulation of biomaterial scaffolds on stem cells, MSCs transdifferentiate into epidermal and dermal cells, and further exert anti-inflammatory, immune-modulative, anti-scarring and antimicrobial properties, significantly improving damaged skin repair [ [3] , [4] , [5] , [6] , [7] ]. Although MSCs-based biomaterials have made great progress in skin regeneration, there are still many limitations: (1) immune rejection [ 8 ]; (2) low cell survival rate [ 9 ]; (3) uncontrolled cell differentiation [ 10 ]; and (4) potential cancer formation [ 11 ]. These defects seriously hinder further researches and clinical application of MSCs-based biomaterials.…”
Section: Introductionmentioning
confidence: 99%
“…With the support and regulation of biomaterial scaffolds on stem cells, MSCs transdifferentiate into epidermal and dermal cells, and further exert anti-inflammatory, immune-modulative, anti-scarring and antimicrobial properties, significantly improving damaged skin repair [ [3] , [4] , [5] , [6] , [7] ]. Although MSCs-based biomaterials have made great progress in skin regeneration, there are still many limitations: (1) immune rejection [ 8 ]; (2) low cell survival rate [ 9 ]; (3) uncontrolled cell differentiation [ 10 ]; and (4) potential cancer formation [ 11 ]. These defects seriously hinder further researches and clinical application of MSCs-based biomaterials.…”
Section: Introductionmentioning
confidence: 99%
“…They differentiate into HSCs in vitro. 23 VSELSCs can be generated from primordial germ cells and undergo further differentiation into HSCs 47 ( Figure 1 ). Bone marrow–derived VSELSCs may not have features characteristic of hematopoietic progenitor SCs, but they can retain hematopoietic features through external-stress growth factors.…”
Section: Very Small Embryonic-like Stem Cellsmentioning
confidence: 99%
“…Allo-HSCT has also been used as a treatment option for acute lymphoid leukemia and multiple myeloma. 1 , 23 , 94 Though alternative treatments remain undefined, it is a valuable treatment tool for hematologic malignancies. Reduced-intensity conditioning after allo-HSCT has been seen in Spain.…”
Section: Hematopoietic Stem-cell Transplantation To Treat Leukemiamentioning
confidence: 99%
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“…These include pluripotent very small embryonic-like stem cells (VSELs) and lineage restricted, tissue-committed stem cells (TCSCs) also termed "progenitors" which include, e.g., hematopoietic stem cells (HSCs) in the bone marrow/cord blood, spermatogonial stem cells (SSCs) in the testes, ovarian stem cells (OSCs) in the ovary, and so on. VSELs selfrenew and give rise to HSCs/SSCs/OSCs by undergoing asymmetrical cell divisions whereas the TCSCs (progenitors) further differentiate into tissue-specific cell types [10]. HSCs differentiate into various types of blood cells, SSCs differentiate into sperm, and OSCs differentiate into oocytes.…”
mentioning
confidence: 99%