2012
DOI: 10.5155/eurjchem.3.2.214-219.588
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Abstract: KEYWORDSTwo series of novel indole-2-carboxylic acid derivatives is reported. In the first series, Nsubstituted derivatives (3a-h) were synthesized via acylation of indole-2-carboxylic acid followed by aldol condensation reaction. Whereas, in the second series, indole-2-carboxamides (5a-g) were synthesized through conversion of acid to its acid chloride followed by coupling of substituted anilines. Structures of the newly synthesized compounds were confirmed by elemental analysis and spectral IR, 1 H NMR and m… Show more

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Cited by 5 publications
(4 citation statements)
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References 22 publications
(18 reference statements)
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“…This study is a continuation of our previous study on the synthesis of new tetracyclic and pentacyclic nonlinear phenothiazine derivatives [ 28 , 29 ]. The synthesized phenothiazine derivatives, 6-chloro-11-azabenzo[a]phenothiazine-5-one and 6-[4-bromophenyl]-10-methyl-11-azabenzo[a]phenothiazine-5-one, were transported from the Chemistry Laboratory of University of Nigeria Nsukka to the Chemistry Laboratory of Godfrey Okoye University, Enugu, Nigeria ( Figure 1 ).…”
Section: Methodsmentioning
confidence: 71%
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“…This study is a continuation of our previous study on the synthesis of new tetracyclic and pentacyclic nonlinear phenothiazine derivatives [ 28 , 29 ]. The synthesized phenothiazine derivatives, 6-chloro-11-azabenzo[a]phenothiazine-5-one and 6-[4-bromophenyl]-10-methyl-11-azabenzo[a]phenothiazine-5-one, were transported from the Chemistry Laboratory of University of Nigeria Nsukka to the Chemistry Laboratory of Godfrey Okoye University, Enugu, Nigeria ( Figure 1 ).…”
Section: Methodsmentioning
confidence: 71%
“…Phenothiazines undergo reversible one-electron oxidation processes with low potentials which lead to stable and deeply coloured radical cations [ 39 ]. New phenothiazines derivatives have been shown to possess antioxidant activity [ 28 ]. This includes benzothiazines [ 40 ], azaphenothiazines, and phenothiazine-aryl amines conjugates via acetyl group [ 41 , 42 ].…”
Section: Resultsmentioning
confidence: 99%
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“…The literature survey approaching towards synthesis of sulphonamide linked pyrazole gathered with 5H-dibenz[b,f]azepine moiety indicates the lack of reference available. In view of these observation and in persistence of our earlier work on different bioactive heterocyclic derivatives [22][23][24][25][26], we envision our approach towards gathering two bioactive entities, 5H-dibenz[b,f]azepine and pyrazole sulphonamide in one compact structure for probing the antimicrobial and antioxidant potentials.…”
Section: Introductionmentioning
confidence: 99%