Novel hydroxyethyl chitosan/cellulose scaffolds with bubble-like porous structure for bone tissue engineering

Wang, Yaping; Qian, Junmin; Zhao, Na; Liu, Ting; Xu, Weiqing; Suo, Aili

doi:10.1016/j.carbpol.2017.03.030

Cited by 68 publications

(21 citation statements)

References 58 publications

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“…As the degree of oxidation increases, the pore diameter increases from 52 ± 10 µm for GE/CGO2 (Figure a,b) to 65 ± 7 and 100 ± 21 µm for GE/CGO5 (Figure c,d) and GE/CGO8 (Figure e,f), respectively. As noted by others, a higher crosslinking degree resulted in more elongated and non‐homogeneous pores. This fact can be ascribed to the faster crosslinking reaction due to the presence of more oxidized groups, which hinders the spatial organization and homogenization of the network.…”

Section: Resultssupporting

confidence: 70%

Oxidized Cashew Gum Scaffolds for Tissue Engineering

Maciel

Azevedo

Correia

et al. 2019

Macro Materials & Eng

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In the last few years, several strategies have been proposed to fabricate scaffolds for tissue engineering (TE) applications; however, they are based on harsh and time‐consuming techniques. The choice for natural polymers such as cashew gum (CG) allows to circumvent the demands of biocompatibility and degradability of TE systems. In this work, CG, a polysaccharide derived from Anacardium occidentale trees, is functionalized with aldehyde groups through periodate oxidation. The resultant oxidized cashew gum (CGO) is mixed with gelatin (GE) to yield a covalently crosslinked hydrogel. CGO/GE sponges are obtained by employing a freeze‐drying methodology to the previously obtained hydrogels. The mechanical properties, swelling ability, and porosity of the GE/CGO sponges are tuned by using CGO with different degrees of oxidation. The resultant sponges can maintain high levels of water absorption and recover their initial mechanical properties after cyclic compression. Moreover, these porous and mechanically robust devices can support the adhesion and proliferation of cells, which can envision their application for the regeneration of soft tissues.

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Section: Resultssupporting

confidence: 70%

Oxidized Cashew Gum Scaffolds for Tissue Engineering

Maciel

Azevedo

Correia

et al. 2019

Macro Materials & Eng

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“…Almodovar et al developed an LbL assembly of polyelectrolyte complexes by using TMC as a polycation and heparin as a polyanion, and the LbL assembly was used as a periosteal mimetic to provide osteoprogenitor cells and improve bone and allograft compatibility [145]. Hydroxyalkyl chitosan derivatives are also used in BTE; however, only hydroxypropyl chitosan (HPCS), hydroxybutyl chitosan (HBCS), and hydroxyethyl chitosan (HECS) are currently in use for bone tissue engineering [146][147][148].…”

Section: Bone Tissue Engineering Materialsmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

601

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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“…Ruan et al developed a silk‐fibroin/chitosan/nano‐hydroxyapatite (SF/CS/nHA) scaffold and cultured BM‐MSCs on it; their results were showed that osteogenic differentiation potential was greatly increased when cultured on this scaffolds in comparison with other groups including SF/CS, SF/CS/nHA, and culture plates groups (Ruan, Yan, Deng, Huang, & Jiang, ). In another study, Wang et al developed a novel scaffold by compositing of hydroxyethyl chitosan (HECS) and cellulose (CEL) and their results were showed that this construct has a great osteoconductivity and biocompatibility when steoblastic MC3T3‐E1 cells cultured on HECS‐CEL scaffold (Wang et al, ).…”

Section: Nanofibrous Fabrication Methodsmentioning

confidence: 99%

Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds

Moradi

Golchin

Hajishafieeha

et al. 2018

Journal Cellular Physiology

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Since bone tissue lesions caused by several reasons and has global outbreak without any attentions to the modernity level of the countries. In the other hands treatment of patients with this problem faced to the several limitations, in this because the future of the bone lesions treatments is related to the future of the bone tissue engineering. This review tries to cover the most suitable stem cells and materials from either natural or synthetic sources for bone tissue engineering. These understanding points would help researchers to further uncover the application of different adult stem cell sources in electrospinning scaffolds, promotion of nanofibrous composite construct design and adult stem cell type selection to enhance cell function and bone tissue engineering, and link laboratory investigations to clinical applications.

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Novel hydroxyethyl chitosan/cellulose scaffolds with bubble-like porous structure for bone tissue engineering

Cited by 68 publications

References 58 publications

Oxidized Cashew Gum Scaffolds for Tissue Engineering

Oxidized Cashew Gum Scaffolds for Tissue Engineering

Chitosan Derivatives and Their Application in Biomedicine

Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds

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