Novel human models for elucidating mechanisms of rate-sensitive H-reflex depression

Chang, Ya‐Ju; Liu, Yu-Ching; Hsu, Mei‐Yu; Fang, Chiung‐Yao; Wong, Alice May‐Kuen; DeJong, Stacey L.; Shields, Richard K.

doi:10.1016/j.bj.2019.07.007

Cited by 7 publications

(15 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eight of the included studies [ 12 , 22 , 24 – 26 , 29 – 31 ] reported significantly higher serum levels of total cholesterol in pre-eclamptic women. Although, seven studies were showed non-significant association between the serum levels of total cholesterol and pre-eclampsia [ 14 , 15 , 20 , 21 , 23 , 27 , 28 ]. The pooled meta-regression analysis showed that there is a statistical significant association between total cholesterol and pre-eclampsia as compared with normotensive pregnant women with the pooled SMD of 0.84 (95% CI: 0.40, 1.29) ( Fig 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…In this sub-categorical analysis 15 studies were included to compare the serum HDL-c levels between pre-eclamptic and normotensive pregnant women [12,14,15,[20][21][22][23][24][25][26][27][28][29][30][31]. Nine of the included studies [12,15,20,21,25,26,28,30,31] showed significantly lower levels of serum HDL-c and three studies [22,24,27] showed higher levels of serum HDL-c in pre-eclamptic group as compared to normotensive pregnant women but, three studies [14,23,29] did not show a significant association between serum HDL-c and pre-eclampsia. The pooled metaregression analysis showed that there is a statistical significant association between serum levels of HDL-c and pre-eclampsia as compared to normotensive pregnant women with the pooled SMD of -0.91 (95% CI: -1.43, -0.39) (Fig 4).…”

Section: Association Of Serum Hdl-cholesterol With Pre-eclampsiamentioning

confidence: 99%

“…In this sub-categorical analysis 15 studies were included to compare the serum LDL-cholesterol levels between pre-eclamptic and normotensive pregnant women [12,14,15,[20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Association Of Serum Ldl-cholesterol With Pre-eclampsiamentioning

confidence: 99%

See 2 more Smart Citations

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

2020

View full text Add to dashboard Cite

Introduction Some studies have reported the association between maternal serum lipid profile abnormalities and pre-eclampsia. However, many studies have reported controversial results. Hence, this systematic review and meta-analysis was planned to generate summarized evidence on the association between maternal serum lipid profiles and pre-eclampsia in African women. Methods Four electronic databases such as; PubMed, Hinari, Google Scholar, and African Journals Online were searched for studies published in English. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument and Newcastle-Ottawa Scale were used for data extraction and quality assessment of the included studies. The meta- regression analysis was performed by Stata 14 software. The standardized mean difference (SMD) values of lipid profiles were computed to assess their association with pre-eclampsia at 95% CI. Results In this review a total of 15 observational studies were included. The mean values of triglyceride (TG), total cholesterol (TC), low density lipoprotein- cholesterol (LDL-c) and very low density lipoprotein- cholesterol (VLDL-c) were significantly higher in pre-eclamptic women as compared with normotensive pregnant women (TG = 229.61±88.27 and 147.00 ± 40.47, TC = 221.46 ± 45.90 and 189.67 ± 39.18, LDL = 133.92 ± 38.77 and 112.41 ± 36.08, VLDL = 41.44 ± 19.68 and 26.64 ± 7.87), respectively. The serum high density lipoprotein cholesterol (HDL-c) level was lower, but it is not statistically significant (HDL-c = 51.02 ± 16.01 and 61.80 ± 25.63) in pre-eclamptic women as compared with controls. The pooled standardized mean difference (SMD) of TG, TC, LDL-C and VLDL-C were significantly increased in pre-eclamptic women as compared with normotensive pregnant women with the SMD of (TG = 1.65 (1.10, 2.21), TC = 0.84 (0.40, 1.29), LDL-C = 0.95 (0.46, 1.45) and VLDL-C = 1.27 (0.72, 1.81)) at 95% CI, respectively, but the pooled SMD of HDL-cholesterol was decreased in pre-eclamptic women as compared with normotensive pregnant women (SMD = -0.91 (95% CI: -1.43, -0.39). Conclusions In this review, the maternal serum levels of TG, TC, LDL-c and VLDL-c were significantly associated with the risk of preeclampsia. However, HDL- cholesterol was not significantly associated but it was lower in pre-eclamptic women. Further, large scale prospective studies should verify these outcomes and it is recommended that lipid profiles should be included as a routine diagnostic test for pre-eclamptic women.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Association Of Serum Hdl-cholesterol With Pre-eclampsiamentioning

confidence: 99%

See 1 more Smart Citation

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

2020

View full text Add to dashboard Cite

show abstract

“…In addition, Earley et al (2010) reported blood glucose levels of growing Charolais bulls of 77.5 mg/dL at PRET, and 104.5 mg/dL immediately after a 24-hour transportation was complete [25]. However, the increase in glucose in RPM during transportation could be related to greater glycogenolysis, associated with the increase in catecholamine's and glucocorticoids which were released after long-duration transportation stress [26].…”

Section: Serum Cortisol Glucose and Creatine Kinasementioning

confidence: 99%

Preconditioning beef cattle for long-duration transportation stress with rumen-protected methionine supplementation: A nutrigenetics study

et al. 2020

View full text Add to dashboard Cite

In general, beef cattle long-distance transportation from cow-calf operations to feedlots or from feedlots to abattoirs is a common situation in the beef industry. The aim of this study was to determine the effect of rumen-protected methionine (RPM) supplementation on a proposed gene network for muscle fatigue, creatine synthesis (CKM), and reactive oxygen species (ROS) metabolism after a transportation simulation in a test track. Angus × Simmental heifers (n = 18) were stratified by body weight (408 ± 64 kg; BW) and randomly assigned to dietary treatments: 1) control diet (CTRL) or 2) control diet + 8 gr/hd/day of topdressed rumen-protected methionine (RPM). After an adaptation period to Calan gates, animals received the mentioned dietary treatment consisting of Bermuda hay ad libitum and a soy hulls and corn gluten feed based supplement. After 45 days of supplementation, animals were loaded onto a trailer and transported for 22 hours (long-term transportation). Longissimus muscle biopsies, BW and blood samples were obtained on day 0 (Baseline), 43 (Pre-transport; PRET), and 46 (Post-transport; POST). Heifers' average daily gain did not differ between baseline and PRET. Control heifer's shrink was 10% of BW while RPM heifers shrink was 8%. Serum cortisol decreased, and glucose and creatine kinase levels increased after transportation, but no differences were observed between treatments. Messenger RNA was extracted from skeletal muscle tissue and gene expression analysis was performed by RT-qPCR. Results showed that AHCY and DNMT3A (DNA methylation), SSPN (Sarcoglycan complex), and SOD2 (Oxidative Stress-ROS) were upregulated in CTRL between baseline and PRET and, decreased between pre and POST while they remained constant for RPM. Furthermore, CKM was not affected by treatments. In conclusion, RPM supplementation may affect ROS production and enhance DNA hypermethylation, after a long-term transportation.

show abstract

“…They combine testing for H-reflex depression with recording of motor evoked potentials (MEP) after direct a motor neuron excitation by transcranial stimulation in all three test groups. Observing no decrease in MEP in any group, the authors provide the most solid experimental evidence in humans that the H-reflex takes place at the pre-synaptic level [42].…”

Section: Major Tom To Motoneuron: H-reflex Depression Happens At the mentioning

confidence: 84%

Tumour travel tours – Why circulating cancer cells value company

Häfner

2020

Biomedical Journal

View full text Add to dashboard Cite

Leptospirosis H-reflex depression a b s t r a c tWelcome to the New Year and a new issue of the Biomedical Journal, where we learn that travelling with company boosts the metastatic potential of circulating tumour cells, as well as that a worm could be an excellent model to study antidiabetic drugs. In addition, we discover another pair of molecular scissors for genetic engineering, how exactly Leptospira wreaks havoc on its run through the host organism, and that hyperparathyroidism brings its own risks, but does not worsen the outcome of papillary thyroid carcinoma. Furthermore, the importance of taking into account differing beauty ideals for aesthetic surgery surveys is discussed, alongside the question how bad isolated local recurrence is in the case of HR þ breast cancer. Finally, we find out that virtual colonoscopy deserves more credit, that the first medical experiment in space was all about the H-reflex, and that it is possible to survive advanced necrotising fasciitis of the face and neck.

show abstract

Novel human models for elucidating mechanisms of rate-sensitive H-reflex depression

Cited by 7 publications

References 40 publications

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis

Preconditioning beef cattle for long-duration transportation stress with rumen-protected methionine supplementation: A nutrigenetics study

Tumour travel tours – Why circulating cancer cells value company

Contact Info

Product

Resources

About