Novel histiocytoses considered in the context of histiocyte subset differentiation

Wood, G. S.

doi:10.1001/archderm.129.2.210

Cited by 12 publications

(11 citation statements)

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“…Thus, post-scabetic nodules are essentially composed of helper T cells and indeterminate cells. Interdigitate cell sarcoma may show the S-100 (+)/CDla (-) phenotype and develop skin lesions, but it is primarily a lymph node tumor (4). Similarly, follicular dendritic sarcoma may express the 5-100 (±) phenotype but it is exclusively a lymph node or soft tissue tumor, and the tumor cells are connected with desmosomes (4); such ultrastructural features were absent in histiocytic cells infiltrating the lesions of our cases.…”

Section: Discussionmentioning

confidence: 64%

Post‐Scabetic Nodules: A Lymphohistiocytic Reaction Rich in Indeterminate Cells

Hashimoto

Fujiwara

Punwaney

et al. 2000

The Journal of Dermatology

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We studied six infants and two adult cases of nodular scabies with immunostains and electron microscopy. All eight cases have had either direct (KOH) or family histories of scabies and were treated with lindane 1% cream or permethrin 5% cream. Family members responded very well, but our patients developed multiple papulo-nodular lesions which were initially very pruritic and, in some cases, persisted from several months to over one year. H & E stain of biopsied tissue sections revealed a heavy perivascular and periappendageal lymphohistiocytic cell infiltration. Immunophenotype of these cells was compatible with Langerhans cells, i.e. CD1A (+), S-100 (+) and HLA-DR (+). Electron microscopy showed that these histiocytic cells satisfied all the ultrastructural criteria of Langerhans cells except for the absence of Birbeck's granules. Lag, a monoclonal antibody for Birbeck's granules, was negative. "Persistent nodules in scabies" or "nodular scabies" seems to represent a prolonged response of indeterminate cells-lymphocytes to mite antigens.

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Section: Discussionmentioning

confidence: 64%

Post‐Scabetic Nodules: A Lymphohistiocytic Reaction Rich in Indeterminate Cells

Hashimoto

Fujiwara

Punwaney

et al. 2000

The Journal of Dermatology

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“…Such observations conclude the era when it could be maintained that SlOO protein was a marker of cellular lineage from the neural crest. The occurrence of SlOO positivity in adipose tissue, skeletal muscle slow-twitch fibers (3), macrophages, lymphoid dendritic cells (55,86,87), embryonic keratinocytes, and a variety of mesenchymal organs (13), reinforces the diversity of SlOO proteins and the possible lineages of positive cells f'rom mesoderm as well as from neuroectoderm and neural crest. SlOO positivity is strong in the histiocytes of Langerhans' cell histiocytosis ('histiocytosis X'), and in indeterminate cell histiocytosis (88), as well as in congenital self-healing histiocytosis (89,90) and interdigitating cell sarcoma (91,92).…”

Section: Cutaneous Aspects Of Sloo Proteinsmentioning

confidence: 87%

The S100 family of multipurpose calcium‐binding proteins

1998

J Cutan Pathol

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Antibodies reactive with S100 protein are useful markers in a diagnostic immunohistochemistry laboratory dealing with cutaneous tumors. However, S100 protein is not a single protein but instead a group of S100 proteins with diverse functions. S100 proteins constitute a family of acidic calcium-binding proteins that are important in intracellular calcium metabolism. Recent evidence that some S100 proteins are secreted makes it likely that they are also involved in cell-cell interactions. The exploration of the status of the different members of the S100 family may yield not only diagnostic clues but also relevant functional information about the cells. Considerable recent progress has been made in our understanding of S100 proteins. This review surveys some of these findings that may be either directly or indirectly relevant to cutaneous pathology.

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“…1 Indeed, several reports associate JXG and LCH, 2 -10 and a rare variant of histiocytosis sharing features of Langerhans cells (S-100 protein +, CD1a+) and macrophages (CD68+) but lacking Birbeck granules (CD207−) has been reported as indeterminate cell histiocytosis (ICH). 11 -15 It is currently accepted that most histiocytoses develop from a CD34+ stem cell which can differentiate along two different pathways depending on the cellular microenvironment. 9,10 It has been speculated that the divergent maturation of this common precursor of Langerhans cells and macrophages may not always be irreversible.…”

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confidence: 99%

“…Langerhans cell histiocytosis (LCH) is the prototype of the Langerhans cell subgroup of histiocytes, whereas the origin of juvenile xanthogranuloma (JXG) remains controversial, although a recent work strongly supports an histiocytic lineage (probably plasmacytoid monocytes) and therefore unrelated to normal dermal dendritic cells . Indeed, several reports associate JXG and LCH, and a rare variant of histiocytosis sharing features of Langerhans cells (S‐100 protein +, CD1a+) and macrophages (CD68+) but lacking Birbeck granules (CD207−) has been reported as indeterminate cell histiocytosis (ICH) …”

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confidence: 99%

Histiocytosis with mixed cell populations

et al. 2016

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Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions. We describe an exceptional case of multiple cutaneous lesions in a 10-year-old boy, in which the coexistence of both LCH and JXG cell populations is found in every single lesion. The presence of Birbeck granules and CD207 (langerin) immunostaining in the LCH component would argue against the diagnosis of indeterminate cell histiocytosis (ICH). This unique case gives additional support to the hypothesis of a potentially common histogenesis for LCH and JXG.

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Novel histiocytoses considered in the context of histiocyte subset differentiation

Cited by 12 publications

References 0 publications

Post‐Scabetic Nodules: A Lymphohistiocytic Reaction Rich in Indeterminate Cells

Post‐Scabetic Nodules: A Lymphohistiocytic Reaction Rich in Indeterminate Cells

The S100 family of multipurpose calcium‐binding proteins

Histiocytosis with mixed cell populations

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