Novel hemostatic agents based on gelatin-microbial transglutaminase mix

Lv, Fang; Cong, Xiaonan; Tang, WM; Han, Yiming; Tang, Yu; Liu, Yongrui; Su, Liqiang; Liu, Mingyao; Jin, Mei; Yi, Zhengfang

doi:10.1007/s11427-015-9019-x

Cited by 11 publications

(6 citation statements)

References 34 publications

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“…Penetrating trauma through solid organs (e.g., hepatic gunshot wounds) can be treated with a hemostatic plug composed of gelatin foam wrapped in oxidized cellulose inserted into the traumatic cavity. Recent novel hemostatic agents induce in situ gel formation via microbial transglutaminase to cross-link gelatin, which showed similar hemostatic effect with stronger adhesion and elasticity in rat liver models compared to Surgiflo [31].…”

Section: Gelatin-based Mechanical Hemostatsmentioning

confidence: 99%

Advances in Topical Hemostatic Agent Therapies: A Comprehensive Update

et al. 2020

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Severe hemorrhage causes significant metabolic and cellular dysfunction secondary to deficient tissue perfusion and oxygen delivery. If bleeding continues, hemodynamic destabilization, hypoxemia, multiple organ failure, and death will occur. Techniques employed to promote hemostasis include surgical suture ligatures, cautery, chemical agents, self-assembling nanoparticles, and physical methods, like mechanical pressure. Improved understanding of the natural clotting cascade has allowed newly designed agents to become more targeted for clinical and military use. Topically-applied hemostatic agents have enormous clinical applications in achieving hemostasis. This manuscript describes currently available and developing topical hemostatic materials, including topical active agents, mechanical agents, synthetic/hemisynthetic hemostatic agents, and external hemostatic dressings for clinical practice.

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Section: Gelatin-based Mechanical Hemostatsmentioning

confidence: 99%

Advances in Topical Hemostatic Agent Therapies: A Comprehensive Update

et al. 2020

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“…The presence of fibrinogen and thrombin results in quick clot formation and good adherence to the bleeding site upon application (Koea et al, 2016). These new products have, however, higher costs and are associated with lower absorption rates and biocompatibility problems (Lv et al, 2017; Msezane et al, 2008). Till now, the clinically used HAs are approved by FDA and/or European Commission (EC), which have rigorous standards and rules, so there were no reported cases of considerable adverse reactions (Msezane et al, 2008).…”

Section: Has and Their Mechanisms Of Actionmentioning

confidence: 99%

“…Gelatin is the result of the partial acid or alkaline hydrolysis of native collagen, being one of the first materials used as HA (Lv et al, 2017; Takagi et al, 2018; Young, Wong, Tabata, & Mikos, 2005). The good hemocompatibility, high blood‐uptake capacity, stability (i.e., it does not fragment easily), and modulation to irregular surfaces are primary features of gelatin, which turns this biopolymer a preferable choice for the development of HAs (Correll & Wise, 1945; Jenkins & Clarke, 1945; Light, 1945a; Light & Prentice, 1945).…”

Section: Has and Their Mechanisms Of Actionmentioning

confidence: 99%

“…Gelfoam® consists on a compressed sponge prepared from purified porcine‐derived gelatin, being its hemostatic activity predominantly mechanical, as any regular gelatin sponge. Further improvements on gelatin‐thrombin HAs led to the development of more efficient devices with better handling properties, enabling its utilization on different types of surgeries (Kabiri, Emami, Rafinia, & Tahriri, 2011; Lv et al, 2017; Takagi et al, 2018). Bak and his team in 2002 described the use of a gelatin‐thrombin sealant in six LPNs for tumors not involving the collecting system (Bak et al, 2004).…”

Section: Has and Their Mechanisms Of Actionmentioning

confidence: 99%

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Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective

et al. 2020

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In recent years, there was an abrupt increase in the incidence of renal tumors, which prompt up the appearance of cutting-edge technology, including minimally invasive and organ-preserving approaches, such as laparoscopic partial nephrectomy (LPN). LPN is an innovative technique used to treat small renal masses that have been gaining popularity in the last few decades due to its promissory results. However, the bleeding control remains the main challenge since the majority of currently available hemostatic agents (HAs) used in other surgical specialities are inefficient in LPN. This hurried the search for effective HAs adapted for LPN surgical peculiarities, which resulted on the emergence of different types of topical HAs. The most promising are the natural origin HAs because of their inherent biodegradability, biocompatibility, and lowest toxicity. These properties turn them top interests' candidates as HAs in LPN. In this review, we present a deep overview on the progress achieved in the design of HAs based on natural origin polymers, highlighting their distinguishable characteristics and providing a clear understanding of their hemostat's role in LPN. This way it may be possible to establish a structure-composition properties relation, so that novel HAs for LPN can be designed to explore current unmet medical needs. K E Y W O R D S biodegradable hemostatic agents, hemostasis, laparoscopic partial nephrectomy, minimally invasive surgeries, renal cell carcinoma 1 | BACKGROUND Kidney cancer is a serious condition, in accordance with the International Agency for Research on Cancer (IARC) it is the 16th most common cause of cancer death and the prevalence has been increasing every year, making kidney cancer considered as a clinically signifi

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“…Unfortunately, any further intervention in the function of the body carries a potential risk. A wide range of traditional materials based on cellulose, collagen, and gelatine are used for varying medical applications [6], but there are now many new fabrics being introduced, including modified sodium starch glycolate, a new chitosan hydroquinone-based gauze, hemostatic agents based on a gelatin-microbial transglutaminase mix, along with other materials with mineral content or metal ion-chelated tannic acid coating [7][8][9][10][11]. Different composites, such as oxycellulose cross-linked gelatin microparticles, a plant-derived oxidized nanofibrillar cellulose-chitosan hemostat and thrombin with a gelatin sponge carrier, have appeared on the market as well [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate

et al. 2020

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The achievement of rapid hemostasis represents a long-term trend in hemostatic research. Specifically, composite materials are now the focus of attention, based on the given issues and required properties. In urology, different materials are used to achieve fast and effective hemostasis. Additionally, it is desirable to exert a positive influence on local tissue reaction. In this study, three nonwoven textiles prepared by a wet spinning method and based on a combination of hyaluronic acid with either oxidized cellulose or carboxymethyl cellulose, along with the addition of etamsylate, were introduced and assessed in vivo using the rat partial nephrectomy model. A significantly shorter time to hemostasis in seconds (p < 0.05), was attributed to the effect of the carboxymethyl cellulose material. The addition of etamsylate did not noticeably contribute to further hemostasis, but its application strengthened the structure and therefore significantly improved the effect on local changes, while also facilitating any manipulation by the surgeons. Specifically, the hyaluronic acid supported the tissue healing and regeneration, and ensured the favorable results of the histological analysis. Moreover, the prepared textiles proved their bioresorbability after a three-day period. In brief, the fabrics yielded favorable hemostatic activity, bioresorbability, non-irritability, and had a beneficial effect on the tissue repair.

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Novel hemostatic agents based on gelatin-microbial transglutaminase mix

Cited by 11 publications

References 34 publications

Advances in Topical Hemostatic Agent Therapies: A Comprehensive Update

Advances in Topical Hemostatic Agent Therapies: A Comprehensive Update

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective

Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate

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