2017
DOI: 10.1038/ncomms13624
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Abstract: The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel l… Show more

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Cited by 263 publications
(285 citation statements)
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“…In comparison, the 8 ICV SNPs explained 0.099 to 0.27% of the variance [78], the 6 hippocampus SNPs 0.092 to 0.32% [77], the 4 putamen SNPs 0.14 to 0.32, while the 1 SNP associated with caudate explained 0.11% of the trait variance [76]. These results are summarised in Figure Our results align with the hypothesis of a simpler genetic architecture of brain structural phenotypes compared to psychiatric diagnoses.…”
Section: Resultssupporting
confidence: 84%
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“…In comparison, the 8 ICV SNPs explained 0.099 to 0.27% of the variance [78], the 6 hippocampus SNPs 0.092 to 0.32% [77], the 4 putamen SNPs 0.14 to 0.32, while the 1 SNP associated with caudate explained 0.11% of the trait variance [76]. These results are summarised in Figure Our results align with the hypothesis of a simpler genetic architecture of brain structural phenotypes compared to psychiatric diagnoses.…”
Section: Resultssupporting
confidence: 84%
“…We included SNPs from the largest GWAS reporting significant associations with MDD (female only, recurrent) [15], schizophrenia [79], Alzheimer's disease [596], volumes of the subcortical structures: putamen, caudate nucleus, and hippocampus, as well as [76], ICV and hippocampal volume [77], We also included SNPs from the GWAS for rheumatoid arthritis [597] to check if our results align with the conclusions from the Bayesian approach [592,594,598]. SNPs used and estimated ! "…”
Section: Methodsmentioning
confidence: 99%
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“…Similarly, improving (or at least preserved) performance into older age has been reported for tasks relying on accrued knowledge and verbal abilities (Park et al 2002;Salthouse 2012). It is also worth noting that the impact of aging on cognition is modulated by health factors (e.g., anxiety, blood pressure) and lifestyle choices (e.g., exercise, diet) in a sex-and brain region-specific fashion, and genetic variations will lead to additional age interactions due to their impact on the brain structure, cognitive abilities, vulnerability to neurodegeneration, and cognitive decline (Coffey et al 1998;Hibar et al 2017;IOM 2015;Kassem et al 2017;Reinvang et al 2013;Salthouse 2012;Xu et al 2000). Altogether, this makes it extremely difficult to compare findings across different studies when looking at the efficacy of possible age-defying interventions, such as meditation.…”
Section: Effects Of Normal Aging On Cognitionmentioning
confidence: 99%