Novel functionally substituted esters based on sodium diethyldithiocarbamate derivatives: Synthesis, characterization, biological activity and molecular docking studies

Karimov, A.Y.; Orujova, Arzu; Taslimi, Parham; Sadeghian, Nastaran; Mammadov, B.A.; Karaman, Halide Sedef; Farzaliyev, Vagif; Sujayev, Afsun; Taş, Recep; Alwasel, Saleh; Gülçın, İlhami

doi:10.1016/j.bioorg.2020.103762

Cited by 53 publications

(37 citation statements)

References 42 publications

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“…One such compound is galantamine and used to treat mild AD to moderate AD [75]. Also, EESB effectively inhibited AChE with IC 50 values of 1.946 μg/mL (r 2 : 0.9752) for AChE, which is the primary cholinesterase at mainly neuromuscular junctions and in chemical synapses in the body [76,77]. However, it was observed that WESB had not any effects against the used metabolic enzymes.…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) – profiling of phenolic compounds by LC-HRMS

Bingöl

Kızıltaş

Gören

et al. 2021

Heliyon

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In order to evaluate the antioxidant activity of evaporated ethanolic extract (EESB) and lyophilized water extract (WESB) of Shaggy bindweed (Convulvulus betonicifolia Mill. Subs), some putative antioxidant methods such as DPPH⋅ scavenging activity, ABTS þ scavenging effect, ferric ions (Fe 3þ ) reduction method, cupric ions (Cu 2þ ) reducing capacity, and ferrous ions (Fe 2þ ) binding activities were separately performed. Also, ascorbic acid, α-tocopherol and BHT were used as the standard compounds. Additionally, some phenolic compounds that responsible for antioxidant abilities of EESB and WESB were screened by liquid chromatography-high resolution mass spectrometry (LC-HRMS). At the same concentration, EESB and WESB demonstrated effective antioxidant abilities when compared to standards. In addition, EESB demonstrated IC 50 values of 1.946 μg/mL against acetylcholinesterase (AChE), 0.815 μg/mL against α-glycosidase and 0.675 μg/mL against α-amylase enzymes.

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Section: Resultsmentioning

confidence: 99%

Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) – profiling of phenolic compounds by LC-HRMS

Bingöl

Kızıltaş

Gören

et al. 2021

Heliyon

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“…Also, MEFO effectively inhibited AChE with IC50 values of 1.946 μg/mL (r 2 : 0.9752) and for AChE. On the other hand, tacrine was used as positive control for AChE inhibition, and had Ki value of 0.124 µM (r 2 : 0.9804) against AChE, which is the primary cholinesterase at mainly neuromuscular junctions and in chemical synapses in the body [74]. However, it was observed that WEFO had not any effects against the used metabolic enzymes.…”

Section: Resultsmentioning

confidence: 99%

Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

Kızıltaş¹,

Gören²,

Bingöl³

et al. 2021

Rec.Nat.Prod.

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To evaluate the antioxidant activity of evaporated ethanolic extract of Ferula orientalis L. (EEFO) and lyophilized water extract of Ferula orientalis L. (WEFO) several in vitro antioxidant methods such as ABTS•+ scavenging activity, DPPH· scavenging activity, Fe3+reduction method, cupric ions (Cu2+) reduction capacity, and metal ion (Fe2+)-binding activities using ferrozine reagent were separately performed. Also, BHT, α-tocopherol and ascorbic acid were used as the standard antioxidant molecules. Moreover, some phenolic compounds that are responsible for antioxidant abilities of EEFO and WEFO were determined by LC-HRMS. EEFO and WEFO demonstrated effective antioxidant abilities when compared with the standards. EEFO demonstrated IC50 values of 1.946 µg/mL against acetylcholinesterase (AChE), 0.815 µg/mL against α-glycosidase, and 0.675 µg/mL against α-amylase.

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“…[ 42 ] In explaining the biological activities of molecules, interactions between pyrazolyl–thiazole derivatives and enzymes are very important, as shown in Figure 5, which has many interactions such as hydrogen bonds, polar and hydrophobic interactions, π–π, and halogen bonds. [ 33,34,43–46 ]…”

Section: Resultsmentioning

confidence: 99%

“…[42] In explaining the biological activities of molecules, interactions between pyrazolyl-thiazole derivatives and enzymes are very important, as shown in Figure 5, which has many interactions such as hydrogen bonds, polar and hydrophobic interactions, π-π, and halogen bonds. [33,34,[43][44][45][46] After comparing the biological activities of pyrazolyl-thiazole derivatives, it is necessary to investigate whether pyrazolyl-thiazole derivatives can be used as active pharmaceutical ingredients in the future. The ADME analysis of molecules should be performed for this examination.…”

Section: Molecular Docking Calculations Of Pyrazolyl-thiazole Derivatmentioning

confidence: 99%

Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α‐glycosidase and molecular docking studies

Demir

Taslimi

Koçyiğit

et al. 2020

Archiv der Pharmazie

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Aldose reductase (AR) is the first and rate-limiting enzyme of the polyol pathway, which converts glucose to sorbitol in an NADPH-dependent reaction. α-Glycosidase breaks down starch and disaccharides to glucose. Hence, inhibition of these enzymes can be regarded a considerable approach in the treatment of diabetic complications. AR was purified from sheep liver using simple chromatographic methods. The inhibitory effects of pyrazolyl-thiazoles ((3aR,4S,7R,7aS)-2-(4-{1-[4-(4-bromophenyl) thiazol-2-yl]-5-(aryl)-4,5-dihydro-1H-pyrazol-3-yl}phenyl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione derivatives; 3a-i) on AR and α-glycosidase enzymes were investigated. All compounds showed a good inhibitory action against AR and α-glycosidase. Among these compounds, compound 3d exhibited the best inhibition profiles against AR, with a K i value of 7.09 ± 0.19 µM, whereas compound 3e showed the lowest inhibition effects, with a K i value of 21.89 ± 1.87 µM. Also, all compounds showed efficient inhibition profiles against α-glycosidase, with K i values in the range of 0.43 ± 0.06 to 2.30 ± 0.48 µM, whereas the K i value of acarbose was 12.60 ± 0.78 µM. Lastly, molecular modeling approaches were implemented to predict the binding affinities of compounds against AR and α-glycosidase. In addition, the ADME analysis of the molecules was performed.

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Novel functionally substituted esters based on sodium diethyldithiocarbamate derivatives: Synthesis, characterization, biological activity and molecular docking studies

Cited by 53 publications

References 42 publications

Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) – profiling of phenolic compounds by LC-HRMS

Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) – profiling of phenolic compounds by LC-HRMS

Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

Determination of the inhibition profiles of pyrazolyl–thiazole derivatives against aldose reductase and α‐glycosidase and molecular docking studies

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