Novel Fe3O4 chitosan–quince-seed mucilage polymeric composite to enhance protein release

Hajivand, Pegah; Ghandi, Faramarz; Akbari, Iman

doi:10.1007/s11696-019-00967-8

Cited by 6 publications

(4 citation statements)

References 61 publications

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“…Besides, mucilage is known to be a common tool for food packaging, as an adjuvant for pharmaceutical preparations, and is used also in the cosmetic industry ( Waghmare et al, 2022 ). Its use in regenerative medicine has been shown in a few studies as an alternative to synthetic polymers, nanocomposites, or as nanocarriers ( Hajivand et al, 2019 ; Yavari Maroufi and Ghorbani 2021 ). Several natural sources of plant mucilage seeds have been mentioned in the literature with different origins, such as seeds from flax, yellow mustard, basil, chia, and quince ( Soukoulis et al, 2018 ).…”

Section: Plant Seed Extracts As Potential Source For Biomedical Scaff...mentioning

confidence: 99%

Emerging applications of 3D engineered constructs from plant seed extracts

Odabaş¹,

Gari̇pcan²,

Ksouri³

2023

Turkish Journal of Biology

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Seeds, by-products derived from various plants such as mango, quince, and apples, are considered waste, though they have emerging commercial potential, and have been used in biological, industrial, and physiological research. Seed-derived natural macromolecules— mainly polysaccharides, mucilage, gums, and cellulose—have physicochemical and structural diversification, giving the potential for forming gels, texturing, thickening, and providing interfacial adsorption. Seed-derived natural macromolecules have been widely used during the last few years in cell research and tissue engineering applications. Their widespread approachability and safety, high rate of biodegradability, biocompatibility, supporting cell proliferation, and extracellular matrix synthesis are the main properties making plant seed derivatives appropriate for use. The gel-forming ability of these derivatives gives them the capability of creating natural polymer-based scaffolds with the aptitude to resemble extracellular matrices (ECM). These ECM exhibit the high potential in scaffolds for tissue renewal. A deeper knowledge of the physicochemical characteristics of seed-derived mucilage and gum has been indicated as a key ingredient in several pharmaceutical preparations, but it has been remarkably utilized in nanomedicine for the last few years as a drug carrier for drug delivery, in gene therapy, and as scaffold components for tissue engineering purposes. Here, we afford up-to-date data about the different extracts from plant seeds—mainly mucilage and gum, we summarize the extraction techniques used to isolate these macromolecules, and we focus on their application in scaffold fabrication for tissue engineering purposes and regenerative medicine applications.

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Section: Plant Seed Extracts As Potential Source For Biomedical Scaff...mentioning

confidence: 99%

Emerging applications of 3D engineered constructs from plant seed extracts

Odabaş¹,

Gari̇pcan²,

Ksouri³

2023

Turkish Journal of Biology

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“…The β (1,4) 2‐amino‐2‐deoxy‐D‐glucopyranose (GlcN) is the main constituent of this biopolymer, which accompanied with N‐acetyl‐D‐glucosamine (GlcNAc) residues 2,3 . However, in spite of holding huge potentials (abundant availability, low cost, and antibacterial activity) and wide applicability, CS's insolubility in water has made it relatively less attractive to exploit in the majority of biomedical fields 4,5 …”

Section: Introductionmentioning

confidence: 99%

“…insolubility in water has made it relatively less attractive to exploit in the majority of biomedical fields. 4,5 In addition to biomedical industries, a number of industries such as water treatment, enhanced oil recovery (EOR) techniques, drilling and fracking industries are highly dependent on water-soluble polymers; this business is expected to reach USD 43.79 billion by 2022. 6 Through another report, due to the environmental concerns and plastic usage restrictions, the water-soluble packaging market is expected to experience 5.0% increase from 2019 to 2025.…”

mentioning

confidence: 99%

Synthesis and wound healing performance of new water‐soluble chitosan derivatives

Shahzadi

Jamal

Hajivand

et al. 2021

J of Applied Polymer Sci

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In present work, an efficient method for the preparation of water‐soluble chitosan (CS) is reported. It is based on simple synthetic method, which is easy to handle and delivered good water solubility. This article describes the effect of various factors such as the concentration of reactants and the amount of solvents on the reactions' outcome as well as cytocompatibility of the resulting water‐soluble CS derivatives. CS derivatives with different ratios of polyethyleneimine (PEI) (80:20 (CP1), 90:20 (CP2), 95:5 (CP3), 99:1 (CP4), and 99.6:0.4 [CP5]), at optimized conditions (50 g of CS, 1 L of 0.5 M acetic acid solution at 80°C for 24 h) were synthesized. It was noted that the amount of PEI was critical for the cytocompatibility, decreasing the amount of PEI led to increasing the cytocompatibility of the obtained water soluble CS derivatives. To show the biomedical and drug delivery applications of the newly synthesized CS derivative, this was used to prepare membranes by freeze‐drying and was loaded with thyroxine, respectively. The angiogenic potential of the thyroxine loaded membranes was tested in chorio allantoic membrane assay, which showed good level of neovascularization. For wound healing studies full thickness wounds rat model was used and thyroxine loaded hydrogels showed complete wound healing at day 23.

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“…Chitosan (CS) is a widely available biopolymer, extractable from marine sources in quite good yield and high purity. 11,12 This is of high potential to attach cells and proliferation and accelerate wound healing. Due to inheriting antibacterial properties including nontoxicity, biocompatibility, mucoadhesive, nonadhesive, and biodegradability, CS has been extensively exploited in the development of biomaterials for wound healing applications.…”

mentioning

confidence: 99%

Developing sulfur‐doped titanium oxide nanoparticles loaded chitosan/cellulose‐based proangiogenic dressings for chronic ulcer and burn wounds healing

et al. 2021

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Development of biomaterials supporting angiogenesis are highly desired in medical applications. In current work, chitosan and cellulose were cross-linked by using triethyl orthoformate and loaded with sulfur-doped titanium oxide nanoparticles. A readily available and inexpensive titanium oxide was added as a potential proangiogenic agent based on our group findings and other reports on metal oxide nanoparticles activity to stimulate angiogenesis. A simple freeze gelation method led to the development of flexible, foldable, and porous membranes. To investigate the chemical characteristics of the synthesized membranes, Fourier-transform infrared spectroscopy was used. Scanning electron microscopy equipped with energy-dispersive X-ray microanalysis was employed for surface morphological investigations. The cross-linked membranes showed higher degree of swelling capacity compared to the same material with titania-loaded nanoparticles in vitro. The synthesized materials showed higher degree of degradation in H 2 O 2 as compared to phosphate-buffered saline and lysozyme. Chorioallantoic membrane assay was done to investigate the angiogenic potential. Titanium oxide nanoparticles loaded membranes (CLHTS-5 wt%) exhibited the best degree of angiogenesis in comparison to the other tested materials. In CLHTS-5 wt% experimental group, a good level of attachment and ingrowth of several blood vessels was observed. Interestingly, the same tested group (CLHTS-5 wt%) had shown the increasing trend of cellular metabolic rate of the seeded cells from Day 0 to Day 7 in vitro. These findings were further confirmed by the decline in lactate dehydrogenase enzyme release which was monitored until 72 h, indicating the promising ability of this biomaterial in wound healing applications.

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Novel Fe3O4 chitosan–quince-seed mucilage polymeric composite to enhance protein release

Cited by 6 publications

References 61 publications

Emerging applications of 3D engineered constructs from plant seed extracts

Emerging applications of 3D engineered constructs from plant seed extracts

Synthesis and wound healing performance of new water‐soluble chitosan derivatives

Developing sulfur‐doped titanium oxide nanoparticles loaded chitosan/cellulose‐based proangiogenic dressings for chronic ulcer and burn wounds healing

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