Novel Coronavirus (2019-nCoV) Outbreak in China: From Local Epidemics to Global Pandemics

Rasool, Ajaz; Ishfaq, Shah; Uqab, Baba

doi:10.2139/ssrn.3559461

Cited by 2 publications

(2 citation statements)

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“…269 Herbacetin 24, rhoifolin and pectolinarin blocked the enzymatic activity of SARS-CoV 3CLpro. 270 Herbacetin, isobavachalcone (25), quercetin 3β-d-glucoside, and helichrysetin (26) blocked the enzymatic activity of MERS-CoV/3CLpro. 271 Robustaflavone (27) inhibited influenza A and influenza B viruses with EC50 values of 2.0 μg/mL and 0.2 μg/mL, respectively.…”

Section: Othersmentioning

confidence: 99%

Drug Development for the Management of Corona Viruses: Insights from Natural Antiviral Agents

Elufioye

Habtemariam

2020

TJNPR

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Coronaviruses (CoVs) are enveloped viruses that cause multiple respiratory and intestinal infections in humans and animals. 1 The term 'coronavirus' refers to the crown-like appearance of CoVs under electron microscope due to spike projections from the membrane. 2 These viruses were first described in the 1960s from patients with respiratory infections like the common cold. 3 Since then, several human coronaviruses (HCoVs) have been identified including the HCoV-Hong Kong University 1 (HKU1), HCoV-NL63; severe acute respiratory syndrome (SARS)-CoV; and Middle East respiratory syndrome (MERS)-CoV. 3 CoVs belong to the subfamilies Coronavirinae and Torovirinae of the family Coronaviridae in the order Nidovirales. 4 Based on phylogeny, they are divided into four genera as α-CoV, β-CoV, γ-CoV and δ-CoV. 5 The beta-CoV genus is further subdivided into four lineages (A, B, C, and D) 1 (Figure 1). Mammalian coronavirus include HCoV-229E and HCoV-NL63 which belong to the α-coronavirus class as well as HCoV-HKU1, SARS-CoV, MERS-CoV and HCoV-OC43 which are β-coronaviruses; while avian coronavirus is the γ-coronavirus and δ-coronavirus. 3 The novel coronavirus, 2019-nCoV, that caused the current global COVID-19 pandemic was first identified in December 2019 in the Wuhan region (Hubei Province) of China. Since then, the Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses has formally designated the virus as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 6

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Section: Othersmentioning

confidence: 99%

Drug Development for the Management of Corona Viruses: Insights from Natural Antiviral Agents

Elufioye

Habtemariam

2020

TJNPR

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“…The suspected reservoir hosts are currently believed to be bats, similar to the SARS epidemic the host body then it gradually multiply and shows its genomic adaptation and hence is able to the different types of genomic adaptation as compared to other virus. Various steps by are mentioned below [38][39][40][41][42][43][44].…”

Section: Risk Factors Of Novel Coronavirusmentioning

confidence: 99%

Covid-19: Epidemiology, Pathogenicity and Global Updates

et al. 2020

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Novel coronavirus (COVID-19) is a highly contagious virus that originated from China and has become a major threat in the current time. Presently, finding an effective treatment strategy for COVID-19 is in infancy. Worldwide, numerous clinical trials employing different treatment strategies (antiviral drugs and vaccines) are in progress to develop an effective therapeutic regimen against COVID-19. Literature related to the epidemiology, mortality, pathogenicity, treatment strategies and clinical data was studied and database was collected using various search engines such as j-gate, google scholar, scihub, pubmed, sciencedirect etc. The present review systematically summarises the published information about epidemiology, various stages of pandemic, mortality, pathogenicity, modes of transmission, clinical characteristics, methods of prevention, ongoing treatment strategies and drugs under clinical trials associated with COVID-19 with a hope to avoid possible threatening of the lives of millions of human beings and provide directions for future studies.

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Novel Coronavirus (2019-nCoV) Outbreak in China: From Local Epidemics to Global Pandemics

Cited by 2 publications

References 0 publications

Drug Development for the Management of Corona Viruses: Insights from Natural Antiviral Agents

Drug Development for the Management of Corona Viruses: Insights from Natural Antiviral Agents

Covid-19: Epidemiology, Pathogenicity and Global Updates

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