Novel Combination of Silver Nanoparticles and Carbon Nanotubes for Plasmonic Photo Thermal Therapy in Melanoma Cancer Model

Abstract

Purpose: Plasmonic photo thermal therapy (PPTT) is a therapeutic method in which the photon energy is rapidly transformed into heat via a series of radiative and non-radiative phenomena to ablate cancer. Plasmonic NPs, such as silver NPs (Ag NPs), have considerable properties in optical absorbance. Furthermore, good thermal conductivity and cell penetration ability of carbon nanotubes (CNTs) could improve the efficacy of Ag NPs for PPTT. Decoration of the multi-walled carbon nanotubes (MWCNTs) with silver has been developed to enhance thermal conductivity of the MWCNT particles.Methods: The Ag NPs were decorated on the CNTs and the ability of these particles (CNT/Ag NPs) in reduction of melanoma tumor size after PTT was evaluated experimentally. For comparison, the PTT of silver nanorods (Ag NRs) and CNTs were investigated. The melanoma tumor was induced by injection of B16/F10 cell line to the inbred mice. Different NPs were injected into the tumors and then irradiated via laser diode (λ=670 nm, P=500 mW, and I= 3.5 W/cm2) at scheduled time.Results: Monitoring of tumor sizes showed that integration of CNTs with silver could enhance the optical absorption of CNTs and improve tumor destruction in PPTT technique.Conclusion: The CNT/Ag NPs could act as a potent agent in PPTT method in curing solid tumors.

Carbon Nanotubes: Smart Drug/Gene Delivery Carriers

“…Studies have shown that after PTT on a murine melanoma cell line B16/F10, histopathology showed cell necrosis of up to 70% and 60% for CNTs/Ag and CNTs, respectively. 105 The same group tested murine melanoma tumor cells with surface modified MWCNTs in which the CNTs were oxidized and then treated with a layer of PEG. This time, cellular necrosis using oxidized MWCNTs coated with a layer of PEG showed more than 90% necrosis (at 1 mg/mL of each sample injected into the tumor at a dose of 200 μL/cm 3 of tumor volume), while the control group only showed 25% necrosis after receiving an 808 nm continuous-wave NIR laser at an intensity of 8 W/cm 2 for 10 min of therapy.…”

Melanoma Cancer Therapy Using PEGylated Nanoparticles and Semiconductor Laser

“…They tuned to absorb laser beam energy at a specific range of wavelengths. 1 Titanium dioxide (TiO2) appears in the world as familiar mineral crystals such as anatase and rutile. 2 TiO2 is efficient to transform solar energy into electrical energy.…”

Fructose-coated Angstrom silver inhibits osteosarcoma growth and metastasis via promoting ROS-dependent apoptosis through the alteration of glucose metabolism by inhibiting PDK

“…Silver has been employed for biomedical purposes since ancient time owing to its anti-microbial properties 17 , 18 . Recent researches on Dalton's lymphoma ascites tumor model 19 , glioblastoma- or melanoma-bearing mice 20 , 21 , and lung or breast cancer-bearing mice 22 - 24 have demonstrated the efficacy of silver NPs (AgNPs) in suppressing tumor growth. More recently, we reported a pure physical method, which avoided the use of any hazardous biological and chemical reducing agents, to fabricate ultra-small silver particles reaching the Ångstrom (Ång; one-tenth of nanometer) sizes 16 .…”