Novel Biotransformation of Digoxigenin by Colletotrichum lini AS3. 4486

Abstract

The biotransformation of digoxigenin by Colletotrichum lini AS3. 4486 was investigated. The conversion reaction was carried out in a 72h process, and the sole products was isolated by column chromatography and elucidated as digoxigenone by HR-ESI-MS, 1 H-NMR , 13 C-NMR and single-crystal X-ray diffraction. The crystal of digoxigenone belongs to triclinic, space group P1 with 7.4017 (15), 7.7450 (15), 10.215 (2) Å , α = 99.51(3), β = 94.70 (3), γ = 114.97 (3)°, Z = 1. This study povides a new method for the synthesis of digoxigenone.