2010
DOI: 10.1007/s00726-010-0519-1
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Abstract: Two novel antimicrobial peptides, named halictines, were isolated from the venom of the eusocial bee Halictus sexcinctus. Their primary sequences were established by ESI-QTOF mass spectrometry, Edman degradation and enzymatic digestion as Gly-Met-Trp-Ser-Lys-Ile-Leu-Gly-His-Leu-Ile-Arg-NH2 (HAL-1), and Gly-Lys-Trp-Met-Ser-Leu-Leu-Lys-His-Ile-Leu-Lys-NH2 (HAL-2). Both peptides exhibited potent antimicrobial activity against Gram-positive and Gram-negative bacteria but also noticeable hemolytic activity. The CD … Show more

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Cited by 59 publications
(76 citation statements)
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“…The peptides were prepared by the solid-phase method as previously described [22][23][24]26]. They were purified by preparative RP-HPLC using a Vydac C-18 column (250 x 10 mm) at a 3.0 ml/min flow rate.…”
Section: Peptidesmentioning
confidence: 99%
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“…The peptides were prepared by the solid-phase method as previously described [22][23][24]26]. They were purified by preparative RP-HPLC using a Vydac C-18 column (250 x 10 mm) at a 3.0 ml/min flow rate.…”
Section: Peptidesmentioning
confidence: 99%
“…The antibacterial activity of the new analogs was determined quantitatively as previously described [22][23][24]26] …”
Section: Antibacterial Activitymentioning
confidence: 99%
See 3 more Smart Citations