Novel animal-bone-meal-supported palladium as a green and efficient catalyst for Suzuki coupling reaction in water, under sunlight

Abstract

Animal-bone-meal-supported palladium (0) was prepared and used as catalyst in the Suzuki coupling reaction in water, under sunlight as an alternative source of energy. This palladium has showed a high catalytic activity than tetrakis(triphenylphosphine) palladium (Pd(PPh 3) 4) in the Suzuki cross-coupling reaction (the reaction of 4-halogenopyridopyrimidine with boronic acids) in water via sunlight as the light source, with no addition of ligands. This green method affords heteroaryls with excellent yields in comparison with the classical method using tetrakis (triphenylphosphine) palladium. The green catalyst did not show any significant loss of activity, even when used up to five times.

Synthesis, antibacterial evaluation, crystal structure, molecular interaction analysis and DFT calculations of novel N-hydroxy-2-(4-methylbenzamido)benzamide

“…Therefore, as continuation of our research into the development of a new process to prepare new heterocyclic and pharmaceutical compounds [20][21][22][23][24][25][26][27][28][29][30][31], in this study, the synthesis of a new benzamide derivative N-hydroxy-2-(4-methylbenzamido)benzamide (5) with excellent yield and the investigation of its antibacterial activity were reported (Scheme 1). A crystallographic study of derivative 5 was conducted, in addition to the description of its molecular interactions, electrostatic surface potential (ESP) and fingerprint plots.…”

Synthesis, antibacterial evaluation, Raman, Crystal Structure and Hirshfeld Surface analysis of a new 3-(4-fluorophenyl)-6-methyl-2-(propylthio)quinazolin-4(3H)-one

“…For these reasons, and based on our recent research aimed at developing a new strategy to access to heterocyclic agents [11][12][13][14][15][16][17]. Herein, we reported the synthesis of new quinazolinone derivative 3-(4-fluorophenyl)-6-methyl-2(propylthio)quinazolin-4(3H)-one (5) with good yield (Scheme 1) and its antibacterial activity was tested.…”

Regioselective palladium-catalyzed Suzuki–Miyaura coupling reaction of 2,4,6-trihalogenopyrido[2,3-d]pyrimidines

“…Because of our experience with these heterocycles [18], we decided to use this methodology to access the trisubstituted pyrido[2, 3-d]pyrimidines at positions C2, C4, and C6 in the isomeric position by SuzukieMiyaura coupling reactions (Scheme 1). Herein, we report the preparation of new trihalogen derivatives 6 and 7 and both regioselectivity functionalized by two different classes of reactions.…”