Novel and Gram‐Scale Green Synthesis of Flutamide

Bandgar, B. P.; Sawant, Sanjay S.

doi:10.1080/00397910500464848

Cited by 23 publications

(12 citation statements)

References 32 publications

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“…It is important to note that although there have been some reports on the formation of acid chlorides using a combination of TCT with tertiary amine bases [30][31][32], in our study, we did not observe formation of acid chlorides after acid activation at low temperature based on TLC which was in accordance with other studies using TCT in amide bond formation [33][34][35][36]. Nevertheless, attempts to isolate the formed intermediate led to rapid decomposition due to its high reactivity [20].…”

Section: Methodssupporting

confidence: 81%

Facile synthesis of N-acylbenzotriazoles from carboxylic acids mediated by 2,4,6-trichloro-1,3,5-triazine and triethylamine

et al. 2015

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Section: Methodssupporting

confidence: 81%

Facile synthesis of N-acylbenzotriazoles from carboxylic acids mediated by 2,4,6-trichloro-1,3,5-triazine and triethylamine

et al. 2015

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“…Because of the commercially importance of APPs, search for the development of a simple, mild, and efficient method is still highly demanded. On the other hand, over the past few years 2,4,6-Trichloro-1,3,5-triazine (cyanuric chloride, CC) has been used in many chemical transformations 19 , especially in conversion of carboxylic acid to ester or amide [20][21][22] , hence using CC in preparation of APPs would be a challenge for the usual routes (A, B, C) being a valid alternative route.…”

Section: Introductionmentioning

confidence: 99%

A NEW METHOD FOR ONE-POT SYNTHESIS OF ARYLOXYPHENOXYPROPIONATE HERBICIDES USING 2,4,6-TRICHLORO-1,3,5-TRIAZINE AND (n-BU)4NI AS A HOMOGENEOUS CATALYST

Kalhor

Dadras

Mobinikhaledi

et al. 2011

J. Chil. Chem. Soc.

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The one-pot reaction of halo-heterocycle, (R)-4-hydroxyphenoxy propionic acid and an alcohol, amine or sulfonamide is described as an efficient method for the synthesis of aryloxyphenoxy propionate hrerbicides by using 2,4,6-trichloro-1,3,5-triazine in the presence of ( n-Bu) 4 NI, as a homogeneous catalyst under mild conditions. The present procedure offers several advantages, such as good yields, short reaction times and easy workup.

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“…In order to achieve optimal conditions for the reaction, the second step was investigated thoroughly. The first step and third step were performed by known methods 4,6,7 with slight modification. In the second step, the reaction conditions such as time of reaction, temperature and molar ratios of reactants were optimised.…”

Section: Resultsmentioning

confidence: 99%

“…Another procedure reports the replacement of activated acylating agents, but 3-trifluoromethylaniline has still been used. 4 The preparation and storage of aniline compounds are difficult. The preparation from nitro compounds is usually using hydrogenation, which on the large scale needs special high pressure equipment and expensive catalysts.…”

mentioning

confidence: 99%