Novel acylflavones from Sideritis syriaca ssp. syriaca

Plioukas, Michael; Termentzi, Aikaterini; Gabrieli, Chrysi; Zervou, Maria; Kefalas, Panagiotis; Kokkalou, Eugene

doi:10.1016/j.foodchem.2010.05.076

Cited by 11 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous reports on S. syriaca were mainly focused on methanol, ethyl acetate, hexane, petroleum ether, and dichloromethane extract as well as its essential oil (Armata et al, 2008;Gonzalez-Burgos & Carretero, 2011;Petreska et al, 2011a;Plioukas et al, 2010;Tsibranska, Tylkowski, Kochanov, & Alipieva, 2011). The objective of the present study was a thorough exploration of the bioactive composition, as well as the antioxidant and antimicrobial properties of mountain tea decoction as it is usually consumed.…”

Section: Introductionmentioning

confidence: 98%

“…In folk medicine, S. syriaca preparations have been used as anti-inflammatory, antimicrobial, antioxidant, analgesic, antirheumatic, and tonic agents, while its decoction is still used as a relief from common cold (Gonzalez-Burgos, Carretero, & Gomez-Serranilos, 2011;Gurib-Fakim, 2006;Koleva et al, 2003). Their pharmacological properties have been mainly attributed to flavonoids, diterpenes and essential oils (Armata, Gabrieli, Termentzi, Zervou, & Kokkalou, 2008;Plioukas et al, 2010;Tirrillini, Pellegrino, Menghini, Pagiotti, & Menghini, 2001).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the phytochemical content, antioxidant activity and antimicrobial properties of mountain tea (Sideritis syriaca) decoction

Goulas

Exarchou

Kanetis

et al. 2014

Journal of Functional Foods

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Evaluation of the phytochemical content, antioxidant activity and antimicrobial properties of mountain tea (Sideritis syriaca) decoction

Goulas

Exarchou

Kanetis

et al. 2014

Journal of Functional Foods

View full text Add to dashboard Cite

“…Recently, aldose reductase-inhibiting activity (12) and antiproliferative, anticholinesterase and selective oestrogen receptor modulator-like effects have been reported (11)(12)(13). The previous studies of the Sideritis species reported the presence of flavonoid aglycones and glycosides, phenolic acids, di-and triterpenoids, fatty acids, coumarins and iridoid glycosides (2,10,12,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Most of the studies on the Sideritis species attributed the previously cited biological activities mainly to phenolic compounds.…”

Section: Introductionmentioning

confidence: 99%

Of the phytochemical research performed to date on sideritis species

Bojović¹,

Janković²,

Potpara³

et al. 2011

Ser J Exp Clin Res

View full text Add to dashboard Cite

From a botanical perspective, the large number of species of the genus Sideritis coupled with the tendency to hybridise between the different species has prompted an accurate study designed to clarify all the controversial points in the botanical classification of this genus. The past phytochemical studies of the Sideritis species have been performed with different extracts from the aerial parts, essential oils and isolated compounds such as diterpenoids, flavonoids or phenylpropanoid glycosides. These investigations have justified the traditional uses for these plants and provided direction for new pharmacological research. In recent years, other compounds such as iridoids, coumarins, lignans and phenylpropanoid glycosides have also been isolated and identified. The results have shown that essential oils act as good antimicrobial agents against both Gram-positive and Gram-negative bacteria and against the Candida albicans fungus. Diterpenoids have shown antimicrobial, anti-inflammatory and antifeedant activity, and flavonoids are active as anti-ulcerous, anti-inflammatory and antioxidant agents. Future research should focus on the pharmacological activity of these isolated compounds to find new active principles and identify their mechanisms of action. In addition, it would be interesting to investigate new pharmacological activities apart from those used in traditional medicine; recent studies have shown that diterpenes and some diterpene derivatives act as effective anti-HIV and antiproliferative agents.

show abstract

“…The previous studies of Sideritis species reported the presence of flavonoid aglycones and glycosides, phenolic acids, di-and triterpenoids, fatty acids, coumarines and iridoid glycosides [3,9,11,[13][14][15][16], and essential oil as well [2]. Most of the studies on Sideritis species attributed the previously cited biological activities mainly to phenolic compounds [9,13]. Rios et al [17] reported that flavonoids were reducing agents able to interact with free radical species (of relevance to autoxidation mechanism) and could prevent generation of inflammatory mediators.…”

mentioning

confidence: 99%

“…Recently, aldose reductase inhibiting activity [9], antiproliferative, anticholinesterase, and selective estrogen receptor modulator-like effects have been reported [10][11][12]. The previous studies of Sideritis species reported the presence of flavonoid aglycones and glycosides, phenolic acids, di-and triterpenoids, fatty acids, coumarines and iridoid glycosides [3,9,11,[13][14][15][16], and essential oil as well [2]. Most of the studies on Sideritis species attributed the previously cited biological activities mainly to phenolic compounds [9,13].…”

mentioning

confidence: 99%

Anti-inflammatory, Gastroprotective, and Cytotoxic Effects ofSideritis scardicaExtracts

et al. 2012

View full text Add to dashboard Cite

Sideritis scardica Griseb. (ironwort, mountain tea), an endemic plant of the Balkan Peninsula, has been used in traditional medicine in the treatment of gastrointestinal complaints, inflammation, and rheumatic disorders. This study aimed to evaluate its gastroprotective and anti-inflammatory activities. Besides, continuously increasing interest in assessing the role of the plant active constituents preventing the risk of cancer was a reason to make a detailed examination of the investigated ethanol, diethyl ether, ethyl acetate, and N-butanol extracts regarding cytotoxicity. Oral administration of the investigated extracts caused a dose-dependent anti-inflammatory effect in a model of carrageenan-induced rat paw edema. Gastroprotective activity of the extracts was investigated using an ethanol-induced acute stress ulcer in rats. The cytotoxic activity of plant extracts was assessed on PBMC, B16, and HL-60 cells and compared to the cytotoxicity of phenolic compounds identified in extracts. Apoptotic and necrotic cell death were analyzed by double staining with fluoresceinisothiocyanate (FITC)-conjugated annexin V and PI. The developed HPLC method enabled qualitative fingerprint analysis of phenolic compounds in the investigated extracts. Compared to the effect of the positive control, the anti-inflammatory drug indomethacine (4 mg/kg), which produced a 50 % decrease in inflammation, diethyl ether and N-butanol extracts exhibited about the same effect in doses of 200 and 100 mg/kg (53.6 and 48.7 %; 48.4 and 49.9 %, respectively). All investigated extracts produced dose-dependent gastroprotective activity with the efficacy comparable to that of the reference drug ranitidine. The diethyl ether extract showed significant dose-dependent cytotoxicity on B16 cells and HL-60 cells, decreasing cell growth to 51.3 % and 77.5 % of control, respectively, when used at 100 µg/mL. It seems that phenolic compounds (apigenin, luteolin, and their corresponding glycosides) are responsible for the diethyl ether extract cytotoxic effect. It also appears that induction of oxidative stress might be involved in its cytotoxicity, since B16 and HL-60 cells increased their ROS production in response to treatment with diethyl ether extract. Neither of the tested extracts nor any phenolic compounds showed significant cytotoxic effect to human PBMC. These results demonstrated the potent anti-inflammatory and gastroprotective activities, as well as the promising cytotoxicity.

show abstract

Novel acylflavones from Sideritis syriaca ssp. syriaca

Cited by 11 publications

References 12 publications

Evaluation of the phytochemical content, antioxidant activity and antimicrobial properties of mountain tea (Sideritis syriaca) decoction

Evaluation of the phytochemical content, antioxidant activity and antimicrobial properties of mountain tea (Sideritis syriaca) decoction

Of the phytochemical research performed to date on sideritis species

Anti-inflammatory, Gastroprotective, and Cytotoxic Effects ofSideritis scardicaExtracts

Contact Info

Product

Resources

About