Eur. J. Chem. volume 2, issue 4, P455-462 2011 DOI: 10.5155/eurjchem.2.4.455-462.171 View Full Text
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Khairy Abdel Hameed Mohsen El-Bayouki, Wahid Mohamed Basyouni, Yahia Abdel Fatah Mohamed, Mohsen Mohamed Aly, Samir Youssef Abbas

Abstract: Novel 4(3H)-quinazolinone derivatives with biologically active moieties were synthesized. Reactions of 2-cyano-N-(6-iodo-2-methyl-4-oxoquinazolin-3(4H)-yl) acetamide with carbon disulfide, isothiocyanates followed by cycloalkylation afforded acrylamide, 1,3-dithiazole, 1,3dithiane, thiazole and pyrazole derivatives. The 2-pyridone derivatives were obtained via reaction of cyanoacetamide with some acetylacetone or arylidenes. Cyclocondensation reaction of cyanoacetamide with o-hydroxy aldehydes furnished chrome…

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