Novel 3D-printed prosthetic composite for reconstruction of massive bone defects in lower extremities after malignant tumor resection

Lu, Yajie; Chen, Guojing; Long, Zuoyao; Li, Minghui; Ji, Chuanlei; Wang, Fengwei; Li, Huanzhang; Lu, Jianxi; Wang, Zhen; Li, Jing

doi:10.1016/j.jbo.2019.100220

Cited by 30 publications

(21 citation statements)

References 39 publications

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“…However, there is still a need for innovative reconstruction options, especially in young patients and locally advanced tumors of the upper limb. Lu et al have demonstrated good clinical results for the reconstruction of intercalary massive bone defects of the femur and tibia in sarcoma patients with 3D printed prostheses combined with beta-triacalcium phosphate bioceramics and/or vascularized fibulae [ 10 ], while Fan et al have reported good results of customized 3D printed titanium prostheses of the clavicle, scapula, and pelvis [ 2 ]. Our cases are the first that describe the results of 3D printed prostheses in the long bones of the upper extremity after resection of the entire affected bone.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of Total Bone Defects following Resection of Malignant Tumors of the Upper Extremity with 3D Printed Prostheses: Presentation of Two Patients with a Follow-Up of Three Years

Ackmann

Klingebiel

Gosheger

et al. 2020

Case Reports in Orthopedics

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Wide tumor resection is the local treatment of choice for patients with primary malignant bone tumors and a prerequisite for long-term survival. We present two patients that underwent total bone resection in the upper limb because of primary malignant bone tumors. The defects were then reconstructed by a 3D printed prosthesis, a procedure that, to our knowledge, has not been reported for bone defects of the upper extremity so far. Complete resection of the affected bone was required in a five-year-old girl with a high-grade osteoblastic osteosarcoma of the humerus and a 53-year-old man with a dedifferentiated leiomyosarcoma of the radius, due to the tumor’s extent. Following neoadjuvant chemotherapy, resection of the entire affected humerus including the axillary nerve took place in the first case and the entire affected radius including parts of the radial nerve in the second case. Approximately three years after surgery, both patients are alive and pain-free. Despite a postoperative drop hand that affected the now 56-year-old man, he is able to carry out everyday activities such as brushing his teeth, writing, and eating. The now eight-year-old girl is also able to engage in normal activities with her left arm such as eating and carrying lightweight objects. Both patients are tumor-free to date.

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Section: Discussionmentioning

confidence: 99%

Reconstruction of Total Bone Defects following Resection of Malignant Tumors of the Upper Extremity with 3D Printed Prostheses: Presentation of Two Patients with a Follow-Up of Three Years

Ackmann

Klingebiel

Gosheger

et al. 2020

Case Reports in Orthopedics

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“…A possible strategy to reduce the infection rate could be the use of a myocutaneous flap; the one most often used in literature is the vertical rectus abdominis myocutaneous flap, harvested from the ipsilateral or from the contralateral side [29,30]. Alternatively, the pedicle anterolateral flap can also be considered [31].…”

Section: Complicationsmentioning

confidence: 99%

3D-Printed Titanium Custom-Made Prostheses in Reconstruction after Pelvic Tumor Resection: Indications and Results in a Series of 14 Patients at 42 Months of Average Follow-Up

Zoccali

Baldi

Attala

et al. 2021

JCM

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Wide resection is currently considered the mainstay treatment for primary bone tumors. When the tumor is located in anatomically complex segments, 3D-Printed Titanium Custom-Made Prostheses (3DPTCMP) are possible reconstructive solutions. The aim of the present paper is to analyze indications, results and complications of a series of 14 patients who underwent pelvis reconstruction with 3DPTCMP after tumor removal from January 2015 to December 2019. Chondrosarcoma was the main histology; indications were tumors located in the acetabular area without enough residual bone to support a cup with an iliac stem, and tumors located near the sacrum-iliac joint. The margins were wide in 12 cases, and marginal and intralesional in one case each. In three cases, resection also included the sacrum-iliac joint, so a spine stabilization was performed and linked to the pelvic prosthesis; The average MSTS score was 46.3%; the 5-year local recurrence-free survival was 85.7%. Wound dehiscences were the main complication, resolved with multiple debridements; nevertheless, prosthesis removal was necessary in one case. Currently, the 3DPTCMP is an effective resource for reconstruction after resection of tumors located in the pelvis. Further studies are necessary to value long-term results; more strategies are necessary to try to reduce the infection rate and improve osteointegration.

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“…Current biomaterials research seeks to identify alternative materials to metals and ceramics, especially for prosthetic and orthopaedic applications [1,2]. Much attention has been paid to polymer-ceramic composites and possible surface modification methods of ceramic fillers to increase their durability [3,4].…”

Section: Introductionmentioning

confidence: 99%

Effect of Calcination Temperature on the Phase Composition, Morphology, and Thermal Properties of ZrO2 and Al2O3 Modified with APTES (3-aminopropyltriethoxysilane)

et al. 2021

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This paper describes the effect of calcination temperature on the phase composition, chemical composition, and morphology of ZrO2 and Al2O3 powders modified with 3-aminopropyltriethoxysilane (APTES). Both ceramic powders were modified by etching in piranha solution, neutralization in ammonia water, reaction with APTES, ultrasonication, and finally calcination at 250, 350, or 450 °C. The obtained modified powders were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, particle size distribution (PSD), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM/EDS), and thermogravimetric analysis (TGA).

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Novel 3D-printed prosthetic composite for reconstruction of massive bone defects in lower extremities after malignant tumor resection

Abstract: Highlights Novel 3D-printed prosthetic composite represents an attractive option for reconstructing massive bone defects. Combination of bioceramics and/or vascularized fibula contribute to long-term stability of prosthesis. P-B reconstruction is recommended for children.

Cited by 30 publications

References 39 publications

Reconstruction of Total Bone Defects following Resection of Malignant Tumors of the Upper Extremity with 3D Printed Prostheses: Presentation of Two Patients with a Follow-Up of Three Years

Reconstruction of Total Bone Defects following Resection of Malignant Tumors of the Upper Extremity with 3D Printed Prostheses: Presentation of Two Patients with a Follow-Up of Three Years

3D-Printed Titanium Custom-Made Prostheses in Reconstruction after Pelvic Tumor Resection: Indications and Results in a Series of 14 Patients at 42 Months of Average Follow-Up

Effect of Calcination Temperature on the Phase Composition, Morphology, and Thermal Properties of ZrO2 and Al2O3 Modified with APTES (3-aminopropyltriethoxysilane)

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