Novel [(3-Nitro-2-Oxo-2h-Chromen-4-Ylamino)-Phenyl]phenyl-Azetidin-2-Ones and Their Antimicrobial Activity

Hoti, Ramiz; Troni, Naser; Nura-Lama, Afërdita; Mulliqi‐Osmani, Gjyle; Ismaili, Hamit; Thaçi, Veprim

doi:10.17628/ecb.2017.6.83-88

Cited by 2 publications

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“…On the other hand, the extraordinary biologically importance of benzothiazole derivatives has generated a constant interest for their synthesis and research. In continuation of our previous studies and in an attempt to synthesize the new derivates [15][16][17] in this paper we had intended to synthesize some new heterocyclic derivatives by condensation of 4-chloro-6-methyl-2H-pyran-2-one and substituted 2-aminobenzothiazole which could serve as propharmaceutical products.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Some New 4-(Benzothiazolylamino)-Pyran-2-One Derivatives and Their Antibacterial Activity

Hoti

Ismaili

Troni

et al. 2017

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4‐Benzothiazolylamino‐6‐methyl‐2H[1]‐pyran‐2‐one 6a , 4‐(4‐Methylbenzothiazolylamino)‐6‐methyl‐2H[1]‐pyran‐2‐one 6b , 4‐(5,6‐dimethylbenzothiazolylamino)‐6‐methyl‐2H[1]‐pyran‐2‐one 6c and substituted 4‐(Benzothiazolylamino)‐6‐methyl‐3‐nitro‐2H[1]‐pyran‐2‐ones 6(d, e) are synthesized by condensation of 4‐Chlor‐6 methylpyran‐2‐ones (2, 4) and corresponding benzithiazolylamines 5(a‐e) under reflux reaction conditions. The antibacterial activity of products 4(a‐d) against Staphylococcus aureus, Clebsiella and Escherichia coli were investigated. Compounds 6(a‐e) showed light bactericide activity against Staphylococcus aureus, Escherichia coli and Clebsiella. Compounds 6e and 6c were more active against Staphylococcus aureus. Compounds 6d and 6b exhibited the strongest activity against Clebsiella, whereas 6e was more active against Escherichia coli. In general there was a driect positive correlation between increasing concentration of the compound and anitbacterial activity.

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Section: Introductionmentioning

confidence: 99%