Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies

El-Sherief, Hany A.M.; Youssif, Bahaa G.M.; Bukhari, Syed Nasir Abbas; Abdel‐Aziz, Mohamed; Abdel‐Rahman, Hamdy M.

doi:10.1016/j.bioorg.2017.12.013

Cited by 136 publications

(80 citation statements)

References 48 publications

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“…5‐(Pyridin‐3‐yl)‐2 H ‐1,2,4‐triazole‐3‐amine ( III ) was synthesized from aminoguanidine sulfate ( II ) and pyridine carboxylic acid ( I ) by heating at 210 °C (Scheme ) with good yield (90–95%) …”

Section: Preparation Of 124‐triazole Derivativesmentioning

confidence: 99%

Exploring recent developments on 1,2,4‐triazole: Synthesis and biological applications

Sathyanarayana

Poojary

2020

J Chinese Chemical Soc

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Triazoles are nitrogen-bearing heterocycles. In the last few decades, researchers have focused on fused heterocycles, as they have better pharmacological effect compared to triazoles alone. Among the two isomers of triazole, this article aims to explore the work carried out on 1,2,4-triazole and N-bridged heterocycles derived from 1,2,4-triazole in last 18 years, highlight different synthetic pathways, and present a brief summary of the different biological activities possessed by 1,2,4-triazole derivatives. The information collected in this article is expected to help researchers to discover novel therapeutic agents for better applications in the field of pharmaceutical science. K E Y W O R D Sbio-organic chemistry, medicinal chemistry, organic chemistry

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Section: Preparation Of 124‐triazole Derivativesmentioning

confidence: 99%

Exploring recent developments on 1,2,4‐triazole: Synthesis and biological applications

Sathyanarayana

Poojary

2020

J Chinese Chemical Soc

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“…Isatin, 1,2,3‐triazole, and coumarin possess a variety of biological and pharmacological properties such as antitubercular , antibacterial , antiviral , antimalarial and anticancer activities, occupying an important position in the development of new drugs. Several isatin‐based or 1,2,3‐triazole or coumarin‐based compounds such as semaxanib, carboxyamidotriazole, and STX64 (Fig.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and In Vitro Anticancer Activities of Diethylene Glycol Tethered Isatin‐1,2,3‐triazole‐coumarin Hybrids

Quan-ping

Guo

Wang

2019

Journal of Heterocyclic Chem

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A series of novel diethylene glycol tethered isatin‐1,2,3‐triazole‐coumarin hybrids 9a–l were designed, synthesized, and evaluated for their in vitro anticancer activities against HepG2 (liver carcinoma), Hela (cervical cancer), A549 (lung adenocarcinoma), DU145 (prostatic cancer), SKOV3 (ovarian carcinoma), MCF‐7 (breast cancer), and drug‐resistant MCF‐7/DOX (doxorubicin‐resistant MCF‐7) human cancer cell lines. The results showed that most of the synthesized hybrids exhibited considerable in vitro activities against the tested seven cancer cell lines, and these hybrids can be acted as starting points for further investigation.

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“…Isatin and triazole derivatives possess diverse biological and pharmacological properties such as antitubercular , antibacterial , antiviral , antimalarial , and anticancer activities, occupying an important position in the drug discovery. Several isatin‐ or triazole‐based compounds such as sunitinib, nintedanib, semaxanib, and carboxyamidotriazole (Fig.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Antitumor Activities of 1,2,3‐triazole‐diethylene Glycol Tethered Isatin Dimers

Fan

Huang

Liu

2018

Journal of Heterocyclic Chem

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A series of novel 1,2,3‐triazole‐diethylene glycol tethered isatin dimers were designed, synthesized, and screened for their in vitro antitumor activities in this paper. All dimers showed promising activities against the tested HepG2, Hela, A549, DU145, SKOV3, MCF‐7, and doxorubicin‐resistant MCF‐7 human cancer cell lines. The most active dimer 7g was >1.55 folds more potent than etoposide against all tested cell lines, warrant further investigation.

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Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies

Cited by 136 publications

References 48 publications

Exploring recent developments on 1,2,4‐triazole: Synthesis and biological applications

Exploring recent developments on 1,2,4‐triazole: Synthesis and biological applications

Design, Synthesis, and In Vitro Anticancer Activities of Diethylene Glycol Tethered Isatin‐1,2,3‐triazole‐coumarin Hybrids

Design, Synthesis and Antitumor Activities of 1,2,3‐triazole‐diethylene Glycol Tethered Isatin Dimers

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