Notopterol mitigates IL-1β-triggered pyroptosis by blocking NLRP3 inflammasome via the JAK2/NF-kB/hsa-miR-4282 route in osteoarthritis

Chen, Ko-Ta; Yeh, Chi-Tai; Yadav, Vijesh Kumar; Pikatan, Narpati Wesa; Fong, Iat-Hang; Lee, Wei-Hwa; Chiu, Yen-Shuo

doi:10.1016/j.heliyon.2024.e28094

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…The activation of inflammation-related factors during pain is associated with the development of pain. Postoperative pain and inflammatory biomarkers, as well as the nucleotide-binding domain and leucine-rich repeat (NLR) family, particularly pyrin domain-containing 3 (NLRP3), play a significant role in the inflammatory response and pain management after surgery for such fractures [50,[200][201][202][203]. The NLRP3 inflammasome is a key component of the innate immune system that regulates the production of pro-inflammatory cytokines, such as IL-1β, which are vital in the inflammatory process.…”

Section: Fascia Iliac Compartment Block (Ficb)-serum Nlrp3 and The Ro...mentioning

confidence: 99%

“…The NLRP3 inflammasome is a key component of the innate immune system that regulates the production of pro-inflammatory cytokines, such as IL-1β, which are vital in the inflammatory process. Managing these inflammatory factors can be critical for controlling postoperative pain and enhancing healing [50,[199][200][201][202][203].…”

Section: Fascia Iliac Compartment Block (Ficb)-serum Nlrp3 and The Ro...mentioning

confidence: 99%

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Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Cocea,

Stoica

2024

JPM

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Inflammation during the perioperative period of joint arthroplasty is a critical aspect of patient outcomes, influencing both the pathophysiology of pain and the healing process. This narrative review comprehensively evaluates the roles of specific cytokines and inflammatory biomarkers in this context and their implications for pain management. Inflammatory responses are initiated and propagated by cytokines, which are pivotal in the development of both acute and chronic postoperative pain. Pro-inflammatory cytokines play essential roles in up-regulating the inflammatory response, which, if not adequately controlled, leads to sustained pain and impaired tissue healing. Anti-inflammatory cytokines work to dampen inflammatory responses and promote resolution. Our discussion extends to the genetic and molecular influences on cytokine production, which influence pain perception and recovery rates post-surgery. Furthermore, the role of PAI-1 in modulating inflammation through its impact on the fibrinolytic system highlights its potential as a therapeutic target. The perioperative modulation of these cytokines through various analgesic and anesthetic techniques, including the fascia iliac compartment block, demonstrates a significant reduction in pain and inflammatory markers, thus underscoring the importance of targeted therapeutic strategies. Our analysis suggests that a nuanced understanding of the interplay between pro-inflammatory and anti-inflammatory cytokines is required. Future research should focus on individualized pain management strategies.

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Section: Fascia Iliac Compartment Block (Ficb)-serum Nlrp3 and The Ro...mentioning

confidence: 99%

Section: Fascia Iliac Compartment Block (Ficb)-serum Nlrp3 and The Ro...mentioning

confidence: 99%

Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Cocea,

Stoica

2024

JPM

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Corydaline attenuates osteolysis in rheumatoid arthritis via mitigating reactive oxygen species production and suppressing calcineurin-Nfatc1 signaling

Lu,

Wang,

Zhang

et al. 2024

International Immunopharmacology

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Phytochemistry and Biological Profile of the Chinese Endemic Herb Genus Notopterygium

Tang,

Zheng,

Chen

et al. 2024

Molecules

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Notopterygium, a plant genus belonging to the Apiaceae family, is utilized in traditional Chinese medicine for its medicinal properties. Specifically, the roots and rhizomes of these plants are employed in phytotherapy to alleviate inflammatory conditions and headaches. This review provides a concise overview of the existing information regarding the botanical description, phytochemistry, pharmacology, and molecular mechanisms of the two Notopterygium species: Notopterygium incisum and N. franchetii. More than 500 distinct compounds have been derived from these plants, with the root being the primary source. These components include volatile oils, coumarins, enynes, sesquiterpenes, organic acids and esters, flavonoids, and various other compounds. Research suggests that Notopterygium incisum and N. franchetii exhibit a diverse array of pharmacological effects, encompassing antipyretic, analgesic, anti-inflammatory, antiarrhythmic, anticoagulant, antibacterial, antioxidant, and anticancer properties on various organs such as the brain, heart, digestive system, and respiratory system. Building activity screening models based on the pharmacological effects of Notopterygium species, as well as discovering and studying the pharmacological mechanisms of novel active ingredients, will constitute the primary development focus of Notopterygium medicinal research in the future.

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Notopterol mitigates IL-1β-triggered pyroptosis by blocking NLRP3 inflammasome via the JAK2/NF-kB/hsa-miR-4282 route in osteoarthritis

Cited by 3 publications

References 47 publications

Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Corydaline attenuates osteolysis in rheumatoid arthritis via mitigating reactive oxygen species production and suppressing calcineurin-Nfatc1 signaling

Phytochemistry and Biological Profile of the Chinese Endemic Herb Genus Notopterygium

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